| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Alvaro Negredo | 35 | 25 | 12 | 10 | 16 | 11 |
Jesus Navas | 34 | 32 | 2 | 2 | 4 | 4 |
Andres Palop | 33 | 33 | 1 | - | - | - |
Renato | 33 | 30 | 6 | 3 | 6 | 4 |
Fernando Navarro | 29 | 26 | 7 | 3 | 3 | - |
Diego Capel | 29 | 14 | 23 | 15 | 9 | 1 |
Diego Perotti | 28 | 22 | 6 | 6 | 14 | 4 |
Adriano | 27 | 23 | 5 | 4 | 6 | - |
Frederic Kanoute | 27 | 20 | 8 | 7 | 11 | 12 |
Didier Zokora | 26 | 25 | 2 | 1 | 3 | - |
Julien Escude | 24 | 24 | 8 | - | 1 | - |
Luis Fabiano | 23 | 18 | 6 | 5 | 7 | 15 |
Lolo | 21 | 9 | 24 | 12 | 3 | 1 |
Ivica Dragutinovic | 20 | 20 | 4 | - | 1 | 2 |
Romaric | 19 | 10 | 20 | 9 | 5 | 1 |
Abdoulay Konko | 18 | 17 | 4 | 1 | 4 | 1 |
Marius Stankevicius | 16 | 14 | 5 | 2 | 3 | - |
Sebastien Squillaci | 16 | 14 | 8 | 2 | 3 | 1 |
Arouna Kone | 11 | 3 | 12 | 8 | 2 | - |
Federico Fazio | 10 | 10 | 2 | - | 2 | 1 |
Aldo Duscher | 10 | 7 | 11 | 3 | 3 | - |
Jose Carlos Fernandez | 10 | 2 | 15 | 8 | 2 | 1 |
Sergio Sanchez | 7 | 6 | 3 | 1 | - | - |
Lautaro Acosta | 6 | 1 | 7 | 5 | 2 | - |
Cala | 5 | 5 | 7 | - | - | 3 |
Javier Varas | 5 | 5 | 32 | - | - | - |
Marc Valiente | 3 | 2 | 8 | 1 | 2 | - |
Rodri | 2 | - | 4 | 2 | - | 1 |
Antonio Luna | 1 | 1 | - | - | - | - |
Javier Ernesto Chevanton | 1 | - | 1 | 1 | - | - |
Enrique Carreno | 1 | - | 3 | 1 | - | - |
Dani Jimenez | - | - | 5 | - | - | - |
Luis Alberto | - | - | 4 | - | - | - |
Manuel Redondo | - | - | 1 | - | - | - | 530 | 418 | 266 | 112 | 112 | 63 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .