| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Nemanja Vidic | 35 | 35 | - | - | 2 | 5 |
Patrice Evra | 35 | 34 | 3 | 1 | 6 | 1 |
Edwin van der Sar | 33 | 33 | 1 | - | - | - |
Nani | 33 | 31 | 3 | 2 | 9 | 9 |
Dimitar Berbatov | 32 | 24 | 10 | 8 | 9 | 20 |
Wayne Rooney | 28 | 25 | 3 | 3 | 4 | 11 |
Michael Carrick | 28 | 23 | 8 | 5 | 5 | - |
Javier Hernandez | 27 | 15 | 18 | 12 | 8 | 13 |
Darren Fletcher | 26 | 24 | 3 | 2 | 2 | 2 |
Ryan Giggs | 25 | 19 | 8 | 6 | 5 | 2 |
Paul Scholes | 22 | 16 | 10 | 6 | 6 | 1 |
John O'Shea | 20 | 18 | 9 | 2 | 4 | - |
Rio Ferdinand | 19 | 19 | 1 | - | - | - |
Anderson | 18 | 14 | 10 | 4 | 9 | 1 |
Rafael Da Silva | 16 | 15 | 10 | 1 | 5 | - |
Chris Smalling | 16 | 11 | 22 | 5 | - | - |
Ji Sung Park | 15 | 13 | 5 | 2 | 6 | 5 |
Jonny Evans | 13 | 11 | 9 | 2 | 2 | - |
Darron Gibson | 12 | 6 | 16 | 6 | 4 | - |
Fabio Da Silva | 11 | 5 | 13 | 6 | 2 | 1 |
Michael Owen | 11 | 1 | 21 | 10 | 1 | 2 |
Luis Antonio Valencia | 10 | 8 | 4 | 2 | 2 | 1 |
Wes Brown | 7 | 4 | 10 | 3 | 1 | - |
Gabriel Obertan | 7 | 3 | 10 | 4 | 1 | - |
Federico Macheda | 7 | 2 | 10 | 5 | 2 | 1 |
Tomasz Kuszczak | 5 | 5 | 27 | - | - | - |
Gary Neville | 3 | 3 | 2 | - | 2 | - |
Bebe | 2 | - | 5 | 2 | 1 | - |
Owen Hargreaves | 1 | 1 | - | - | 1 | - |
Ben Amos | - | - | 6 | - | - | - |
Joshua King | - | - | 1 | - | - | - |
Anders Lindegaard | - | - | 4 | - | - | - |
Corry Evans | - | - | 2 | - | - | - |
Oliver Gill | - | - | 2 | - | - | - | 517 | 418 | 266 | 99 | 99 | 75 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .