| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Aaron Hughes | 38 | 38 | - | - | 1 | 1 |
Danny Murphy | 37 | 37 | - | - | 16 | - |
Brede Hangeland | 37 | 37 | - | - | - | 6 |
Clint Dempsey | 37 | 35 | 2 | 2 | 7 | 12 |
Mark Schwarzer | 31 | 31 | - | - | - | - |
Simon Davies | 30 | 25 | 10 | 5 | 8 | 4 |
Chris Baird | 29 | 25 | 9 | 4 | 2 | 2 |
Dickson Etuhu | 28 | 23 | 8 | 5 | 7 | 2 |
Andrew Johnson | 28 | 15 | 12 | 13 | 6 | 3 |
Zoltan Gera | 27 | 10 | 21 | 17 | 3 | 1 |
Damien Duff | 24 | 22 | 5 | 2 | 9 | 4 |
Moussa Dembele | 24 | 22 | 3 | 2 | 7 | 3 |
Carlos Salcido | 23 | 22 | 9 | 1 | 3 | - |
John Pantsil | 16 | 15 | 11 | 1 | 2 | - |
Bobby Zamora | 13 | 9 | 5 | 4 | 6 | 5 |
Steve Sidwell | 12 | 10 | 4 | 2 | - | 2 |
Eddie Johnson | 11 | 1 | 13 | 10 | 1 | - |
Stephen Kelly | 10 | 8 | 19 | 2 | 1 | - |
Diomansy Kamara | 10 | 7 | 11 | 3 | 5 | 2 |
Jonathan Greening | 10 | 6 | 29 | 4 | 3 | - |
Eidur Gudjohnsen | 10 | 4 | 9 | 6 | 3 | - |
David Stockdale | 7 | 7 | 27 | - | - | - |
Gael Kakuta | 7 | 2 | 11 | 5 | 1 | 1 |
Matthew Briggs | 3 | 3 | 3 | - | 2 | - |
Philippe Senderos | 3 | 3 | 2 | - | - | - |
Bjorn Helge Riise | 3 | - | 11 | 3 | - | - |
Paul Konchesky | 1 | 1 | - | - | - | - |
Kagisho Dikgacoi | 1 | - | 7 | 1 | - | - |
Rafik Halliche | 1 | - | 11 | 1 | - | - |
David Elm | - | - | 1 | - | - | - |
Neil Etheridge | - | - | 8 | - | - | - |
Pascal Zuberbuhler | - | - | 3 | - | - | - |
Danny Hoesen | - | - | 1 | - | - | - |
Fredrik Stoor | - | - | 1 | - | - | - | 511 | 418 | 266 | 93 | 93 | 48 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .