| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Nicolas Burdisso | 8 | 8 | - | - | 1 | - |
Marco Borriello | 8 | 5 | 3 | 3 | - | 4 |
Daniele De Rossi | 7 | 7 | - | - | - | 1 |
Marco Cassetti | 7 | 6 | 1 | 1 | 1 | - |
Francesco Totti | 7 | 6 | 2 | 1 | 1 | 2 |
Simone Perrotta | 6 | 6 | - | - | 2 | 1 |
Philippe Mexes | 6 | 6 | - | - | - | 1 |
Jeremy Menez | 6 | 5 | 1 | 1 | 3 | 2 |
John Arne Riise | 5 | 5 | - | - | 2 | - |
Mirko Vucinic | 5 | 5 | 1 | - | 5 | - |
David Pizarro | 5 | 4 | 1 | 1 | - | - |
Matteo Brighi | 5 | 4 | 3 | 1 | 1 | - |
Paolo Castellini | 4 | 2 | 4 | 2 | - | - |
Julio Sergio | 3 | 3 | - | - | - | - |
Bogdan Lobont | 3 | 3 | 5 | - | - | - |
Rodrigo Taddei | 3 | 3 | 1 | - | 1 | - |
Juan | 3 | 3 | 5 | - | - | - |
Fabio Simplicio | 3 | 2 | 4 | 1 | - | - |
Leandro Greco | 3 | 1 | 5 | 2 | 1 | 1 |
Doni | 2 | 2 | 3 | - | - | - |
Aleandro Rosi | 2 | 1 | 1 | 1 | - | - |
Cicinho | 2 | 1 | 5 | 1 | 1 | - |
Julio Baptista | 1 | - | 2 | 1 | - | - |
Guillermo Burdisso | 1 | - | 2 | 1 | - | - |
Adriano | 1 | - | 4 | 1 | - | - |
Gianluca Caprari | 1 | - | 1 | 1 | - | - |
Stefano Okaka | - | - | 2 | - | - | - | 107 | 88 | 56 | 19 | 19 | 12 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .