| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Alvaro Negredo | 38 | 29 | 9 | 9 | 13 | 20 |
Diego Perotti | 31 | 27 | 6 | 4 | 10 | 3 |
Fernando Navarro | 30 | 30 | 2 | - | 3 | - |
Julien Escude | 28 | 27 | 9 | 1 | 1 | 2 |
Frederic Kanoute | 28 | 19 | 9 | 9 | 5 | 12 |
Romaric | 26 | 19 | 9 | 7 | 8 | 1 |
Diego Capel | 26 | 17 | 16 | 9 | 9 | - |
Martin Caceres | 25 | 24 | 5 | 1 | 1 | 1 |
Mouhamadou Dabo | 24 | 21 | 11 | 3 | 3 | - |
Renato | 24 | 12 | 21 | 12 | 4 | 2 |
Didier Zokora | 22 | 17 | 14 | 5 | 8 | - |
Alexis | 21 | 21 | 11 | - | 1 | - |
Javier Varas | 21 | 19 | 18 | 2 | - | - |
Luis Fabiano | 21 | 16 | 7 | 5 | 11 | 10 |
Alejandro Alfaro | 20 | 8 | 20 | 12 | 6 | 2 |
Andres Palop | 19 | 19 | 11 | - | 1 | - |
Federico Fazio | 19 | 17 | 3 | 2 | 1 | 1 |
Jesus Navas | 15 | 15 | - | - | 1 | 1 |
Gary Medel | 15 | 15 | 1 | - | 5 | - |
Ivan Rakitic | 11 | 11 | - | - | 3 | 5 |
Abdoulay Konko | 11 | 9 | 3 | 2 | 1 | 2 |
Lautaro Acosta | 10 | 2 | 16 | 8 | 1 | - |
Tiberio Guarente | 9 | 5 | 4 | 4 | 1 | - |
Sergio Sanchez | 7 | 6 | 5 | 1 | - | - |
Luca Cigarini | 6 | 5 | 10 | 1 | 4 | - |
Jose Carlos Fernandez | 6 | 2 | 10 | 4 | 2 | - |
Rodri | 5 | 2 | 10 | 3 | 2 | - |
Antonio Luna | 2 | 2 | 1 | - | 1 | - |
Luis Alberto | 2 | 1 | 3 | 1 | 1 | - |
Arouna Kone | 1 | - | 6 | 1 | - | - |
Ivica Dragutinovic | 1 | - | 7 | 1 | - | - |
Dani Jimenez | - | - | 9 | - | - | - |
Jose Campana | - | - | 1 | - | - | - | 524 | 417 | 267 | 107 | 107 | 62 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .