| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Brede Hangeland | 38 | 38 | - | - | - | - |
Clint Dempsey | 37 | 37 | - | - | 3 | 17 |
John Arne Riise | 36 | 35 | 1 | 1 | 2 | - |
Danny Murphy | 36 | 33 | 3 | 3 | 18 | 2 |
Moussa Dembele | 36 | 33 | 3 | 3 | 9 | 2 |
Mark Schwarzer | 30 | 30 | - | - | - | - |
Damien Duff | 28 | 23 | 10 | 5 | 5 | 2 |
Bryan Ruiz | 27 | 17 | 10 | 10 | 8 | 2 |
Stephen Kelly | 24 | 21 | 12 | 3 | - | - |
Dickson Etuhu | 22 | 9 | 21 | 13 | 2 | - |
Philippe Senderos | 21 | 21 | 11 | - | 2 | 1 |
Andrew Johnson | 20 | 13 | 8 | 7 | 5 | 3 |
Aaron Hughes | 19 | 18 | 14 | 1 | 1 | - |
Chris Baird | 19 | 13 | 15 | 6 | 1 | - |
Kerim Frei | 16 | 6 | 23 | 10 | 4 | - |
Bobby Zamora | 15 | 14 | 1 | 1 | 5 | 5 |
Steve Sidwell | 14 | 12 | 5 | 2 | 1 | 1 |
Pavel Pogrebnyak | 12 | 12 | - | - | 6 | 6 |
Mahamadou Diarra | 11 | 8 | 3 | 3 | 3 | 1 |
David Stockdale | 8 | 8 | 15 | - | - | - |
Pajtim Kasami | 7 | 3 | 20 | 4 | 3 | - |
Orlando Sa | 7 | 3 | 12 | 4 | 2 | 1 |
Simon Davies | 6 | 3 | 5 | 3 | 1 | - |
Zdenek Grygera | 5 | 5 | 2 | - | 2 | - |
Alexander Kacanikilic | 4 | 2 | 5 | 2 | 2 | - |
Matthew Briggs | 2 | 1 | 17 | 1 | - | - |
Marcel Gecov | 2 | - | 17 | 2 | - | - |
Marcelo Trotta | 1 | - | 7 | 1 | - | - |
Bjorn Helge Riise | - | - | 2 | - | - | - |
Neil Etheridge | - | - | 23 | - | - | - |
Rafik Halliche | - | - | 1 | - | - | - | 503 | 418 | 266 | 85 | 85 | 43 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .