| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Antonio Nocerino | 35 | 33 | 3 | 2 | 4 | 10 |
Zlatan Ibrahimovic | 32 | 32 | - | - | 3 | 28 |
Christian Abbiati | 31 | 31 | 1 | - | 2 | - |
Urby Emanuelson | 30 | 17 | 17 | 13 | 6 | 2 |
Ignazio Abate | 29 | 29 | - | - | 1 | - |
Robinho | 28 | 21 | 8 | 7 | 17 | 6 |
Thiago Silva | 27 | 27 | - | - | 2 | 2 |
Mark van Bommel | 25 | 22 | 7 | 3 | 4 | - |
Alberto Aquilani | 23 | 14 | 12 | 9 | 6 | 1 |
Massimo Ambrosini | 22 | 17 | 10 | 5 | 8 | 1 |
Stephan El Shaaraway | 22 | 6 | 25 | 16 | 5 | 2 |
Daniele Bonera | 20 | 17 | 16 | 3 | 3 | - |
Luca Antonini | 20 | 17 | 8 | 3 | 4 | - |
Kevin-Prince Boateng | 19 | 15 | 4 | 4 | 7 | 5 |
Clarence Seedorf | 18 | 14 | 7 | 4 | 8 | 2 |
Alessandro Nesta | 17 | 16 | 4 | 1 | 1 | 1 |
Antonio Cassano | 16 | 11 | 6 | 5 | 6 | 3 |
Philippe Mexes | 14 | 13 | 8 | 1 | - | - |
Sulley Muntari | 13 | 13 | - | - | 4 | 3 |
Gianluca Zambrotta | 12 | 10 | 11 | 2 | 3 | 1 |
Mario Yepes | 11 | 10 | 16 | 1 | 1 | 1 |
Alexandre Pato | 11 | 7 | 4 | 4 | 6 | 1 |
Marco Amelia | 9 | 7 | 28 | 2 | - | - |
Djamel Mesbah | 8 | 7 | 5 | 1 | - | - |
Maxi Lopez | 8 | 2 | 12 | 6 | 1 | 1 |
Filippo Inzaghi | 7 | - | 15 | 7 | - | 1 |
Gennaro Gattuso | 6 | 4 | 7 | 2 | 3 | - |
Taye Taiwo | 4 | 4 | 7 | - | 1 | - |
Mattia De Sciglio | 3 | 2 | 4 | 1 | - | - |
Mathieu Flamini | 2 | - | 2 | 2 | - | 1 |
Alexander Merkel | 1 | - | 1 | 1 | - | - |
Rodney Strasser | 1 | - | 1 | 1 | - | - |
Ricardo Ferreira | - | - | 1 | - | - | - |
Adria Carmona | - | - | 1 | - | - | - |
Mattia Valoti | - | - | 5 | - | - | - |
Flavio Roma | - | - | 9 | - | - | - | 524 | 418 | 265 | 106 | 106 | 72 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .