| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Bojan Krkic | 33 | 13 | 23 | 20 | 8 | 7 |
Daniele De Rossi | 32 | 32 | - | - | 2 | 4 |
Gabriel Heinze | 31 | 28 | 9 | 3 | - | - |
Miralem Pjanic | 30 | 29 | 3 | 1 | 14 | 3 |
Fernando Gago | 30 | 24 | 8 | 6 | 8 | 1 |
Maarten Stekelenburg | 29 | 29 | - | - | 1 | - |
Erik Lamela | 29 | 23 | 6 | 6 | 12 | 4 |
Francesco Totti | 27 | 26 | 3 | 1 | 8 | 8 |
Jose Angel | 27 | 24 | 12 | 3 | 1 | - |
Dani Osvaldo | 26 | 24 | 3 | 2 | 6 | 11 |
Rodrigo Taddei | 24 | 24 | 10 | - | - | 1 |
Fabio Borini | 24 | 20 | 7 | 4 | 8 | 9 |
Simon Kjaer | 22 | 20 | 7 | 2 | 5 | - |
Aleandro Rosi | 21 | 21 | 8 | - | 5 | - |
Simone Perrotta | 20 | 9 | 23 | 11 | 4 | - |
Leandro Greco | 19 | 9 | 16 | 10 | 7 | - |
Fabio Simplicio | 19 | 9 | 17 | 10 | 6 | 4 |
Juan | 15 | 15 | 2 | - | 6 | 3 |
Marquinho | 15 | 10 | 5 | 5 | 2 | 3 |
Nicolas Burdisso | 10 | 8 | 2 | 2 | - | 1 |
Bogdan Lobont | 9 | 7 | 10 | 2 | - | - |
Marco Cassetti | 7 | 3 | 12 | 4 | - | - |
Marco Borriello | 7 | 2 | 11 | 5 | 2 | - |
David Pizarro | 6 | 4 | 3 | 2 | 3 | - |
Federico Viviani | 6 | 2 | 11 | 4 | 1 | - |
Gianluca Curci | 3 | 2 | 25 | 1 | - | - |
Cicinho | 2 | 1 | 9 | 1 | 1 | - |
Giammario Piscitella | 2 | - | 9 | 2 | - | - |
Junior Tallo | 2 | - | 4 | 2 | - | - |
Gianluca Caprari | 1 | - | 4 | 1 | - | - |
Federico Ricci | - | - | 2 | - | - | - |
Mirko Pigliacelli | - | - | 2 | - | - | - | 528 | 418 | 266 | 110 | 110 | 59 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .