| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Samir Handanovic | 37 | 37 | - | - | - | - |
Danilo | 37 | 37 | - | - | 1 | 1 |
Antonio Di Natale | 36 | 35 | 1 | 1 | 12 | 23 |
Kwadwo Asamoah | 31 | 31 | - | - | 3 | 3 |
Dusan Basta | 31 | 31 | - | - | 8 | 5 |
Muarizio Domizzi | 31 | 30 | 2 | 1 | 4 | 1 |
Giampiero Pinzi | 28 | 27 | 2 | 1 | 5 | 2 |
Pablo Armero | 28 | 25 | 10 | 3 | 3 | - |
Mehdi Benatia | 27 | 27 | - | - | 1 | 1 |
Antonio Floro Flores | 27 | 13 | 15 | 14 | 6 | 4 |
Almen Abdi | 22 | 8 | 19 | 14 | 5 | - |
Mauricio Isla | 21 | 21 | - | - | 7 | 3 |
Giovanni Pasquale | 21 | 13 | 17 | 8 | 4 | - |
Gabriel Torje | 21 | 12 | 25 | 9 | 11 | 2 |
Gelson Fernandes | 16 | 12 | 8 | 4 | 2 | 1 |
Michele Pazienza | 15 | 12 | 6 | 3 | 3 | 1 |
Damiano Ferronetti | 15 | 11 | 8 | 4 | 1 | 1 |
Diego Fabbrini | 13 | 8 | 18 | 5 | 7 | 2 |
Roberto Pereyra | 11 | 7 | 9 | 4 | 5 | 1 |
Emmanuel Agyemang-Badu | 10 | 6 | 9 | 4 | - | - |
Joel Ekstrand | 10 | 5 | 18 | 5 | 1 | - |
Andrea Coda | 7 | 6 | 11 | 1 | 3 | - |
Paulo Barreto | 7 | 2 | 9 | 5 | 2 | - |
Neuton | 4 | 1 | 16 | 3 | - | - |
Cristian Battocchio | 4 | - | 8 | 4 | - | - |
Gabriele Angella | 1 | 1 | - | - | - | - |
Tape Doubai | 1 | - | 11 | 1 | - | - |
Jean-Alain Fanchone | - | - | 1 | - | - | - |
Matej Vydra | - | - | 1 | - | - | - |
Abdoul Sissoko | - | - | 4 | - | - | - |
Daniele Padelli | - | - | 38 | - | - | - | 512 | 418 | 266 | 94 | 94 | 51 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .