| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Jesus Navas | 37 | 37 | - | - | - | 5 |
Ivan Rakitic | 36 | 19 | 18 | 17 | 12 | - |
Fernando Navarro | 35 | 35 | - | - | 4 | - |
Piotr Trochowski | 35 | 27 | 8 | 8 | 16 | 1 |
Manu Del Moral | 34 | 25 | 10 | 9 | 12 | 10 |
Gary Medel | 31 | 30 | 2 | 1 | 5 | 2 |
Alvaro Negredo | 30 | 28 | 3 | 2 | 14 | 14 |
Federico Fazio | 28 | 25 | 8 | 3 | 1 | 2 |
Coke | 28 | 24 | 12 | 4 | 3 | - |
Frederic Kanoute | 26 | 12 | 15 | 14 | 6 | 4 |
Javier Varas | 25 | 25 | 13 | - | - | - |
Julien Escude | 24 | 24 | 6 | - | 1 | 1 |
Emir Spahic | 22 | 22 | - | - | 2 | - |
Jose Antonio Reyes | 19 | 15 | 4 | 4 | 12 | 1 |
Diego Perotti | 16 | 13 | 5 | 3 | 8 | - |
Jose Campana | 15 | 3 | 28 | 12 | 3 | - |
Martin Caceres | 14 | 13 | 5 | 1 | 1 | 1 |
Antonio Luna | 14 | 11 | 15 | 3 | 4 | 1 |
Andres Palop | 13 | 13 | 17 | - | - | - |
Emiiliano Armenteros | 13 | 4 | 12 | 9 | 2 | - |
Baba Diawara | 11 | 2 | 17 | 9 | 1 | 3 |
Cala | 8 | 7 | 9 | 1 | 2 | 1 |
Luis Alberto | 6 | - | 12 | 6 | - | - |
Deivid | 5 | 3 | 6 | 2 | 3 | - |
Tiberio Guarente | 3 | - | 8 | 3 | - | - |
Alexis | 1 | 1 | 12 | - | - | 1 |
Hiroshi Ibusuki | 1 | - | 2 | 1 | - | - |
Dani Jimenez | - | - | 1 | - | - | - |
Salva | - | - | 1 | - | - | - |
Sergio Rico | - | - | 2 | - | - | - |
Julian Cuesta | - | - | 5 | - | - | - |
Tom de Mul | - | - | 9 | - | - | - | 530 | 418 | 265 | 112 | 112 | 47 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .