| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Marek Hamsik | 38 | 37 | 1 | 1 | 12 | 10 |
Morgan De Sanctis | 34 | 34 | 2 | - | - | - |
Edinson Cavani | 34 | 33 | 1 | 1 | 1 | 29 |
Gokhan Inler | 34 | 25 | 10 | 9 | 11 | 6 |
Blerim Dzemaili | 34 | 19 | 17 | 15 | 5 | 7 |
Valon Behrami | 33 | 32 | 2 | 1 | 9 | - |
Goran Pandev | 33 | 25 | 8 | 8 | 16 | 6 |
Paolo Cannavaro | 32 | 32 | 1 | - | 3 | 1 |
Camilo Zuniga | 32 | 30 | 4 | 2 | 8 | - |
Lorenzo Insigne | 32 | 15 | 20 | 17 | 9 | 5 |
Christian Maggio | 31 | 31 | 4 | - | 7 | 4 |
Hugo Campagnaro | 28 | 27 | 4 | 1 | 1 | 1 |
Alessandro Gamberini | 25 | 24 | 14 | 1 | 12 | 1 |
Miguel Britos | 22 | 22 | 5 | - | 5 | - |
Giandomencio Mesto | 16 | 7 | 27 | 9 | 3 | 1 |
Pablo Armero | 15 | 4 | 13 | 11 | 1 | - |
Eduardo Vargas | 9 | - | 19 | 9 | - | - |
Rolando | 7 | 4 | 12 | 3 | 1 | - |
Andrea Dossena | 7 | 3 | 14 | 4 | 2 | - |
Omar El Kaddouri | 7 | 1 | 28 | 6 | 1 | - |
Emanuele Calaio | 6 | 1 | 16 | 5 | 1 | - |
Salvatore Aronica | 5 | 3 | 12 | 2 | 2 | - |
Antonio Rosati | 4 | 4 | 34 | - | - | - |
Marco Donadel | 4 | 1 | 35 | 3 | - | - |
Roberto Insigne | 3 | 1 | 2 | 2 | - | - |
Gianluca Grava | 2 | 2 | 31 | - | 1 | - |
Federico Fernandez | 2 | 1 | 21 | 1 | - | - |
Bruno Uvini | - | - | 9 | - | - | - |
Davide Bariti | - | - | 1 | - | - | - |
Roberto Colombo | - | - | 29 | - | - | - | 529 | 418 | 396 | 111 | 111 | 71 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .