| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Jose Callejon | 37 | 32 | 5 | 5 | 10 | 15 |
Lorenzo Insigne | 37 | 25 | 13 | 12 | 5 | 3 |
Dries Mertens | 33 | 21 | 15 | 12 | 10 | 11 |
Raul Albiol | 32 | 30 | 3 | 2 | 2 | 1 |
Gokhan Inler | 32 | 30 | 7 | 2 | 7 | 2 |
Gonzalo Higuain | 32 | 28 | 4 | 4 | 14 | 17 |
Pepe Reina | 30 | 30 | 5 | - | 3 | - |
Goran Pandev | 29 | 17 | 20 | 12 | 15 | 7 |
Marek Hamsik | 28 | 23 | 9 | 5 | 16 | 7 |
Federico Fernandez | 26 | 25 | 7 | 1 | - | - |
Blerim Dzemaili | 24 | 18 | 18 | 6 | 6 | 6 |
Christian Maggio | 22 | 22 | 4 | - | 1 | - |
Valon Behrami | 21 | 16 | 13 | 5 | 3 | - |
Miguel Britos | 16 | 15 | 17 | 1 | 1 | 1 |
Duvan Zapata | 16 | 6 | 29 | 10 | 4 | 5 |
Faouzi Ghoulam | 15 | 14 | 2 | 1 | - | - |
Jorginho | 15 | 12 | 4 | 3 | 2 | - |
Pablo Armero | 14 | 9 | 10 | 5 | - | - |
Anthony Reveillere | 13 | 13 | 10 | - | 5 | - |
Giandomencio Mesto | 11 | 10 | 10 | 1 | 1 | - |
Henrique | 11 | 8 | 7 | 3 | 1 | 1 |
Rafael Cabral | 8 | 7 | 17 | 1 | - | - |
Josip Radosevic | 7 | - | 31 | 7 | - | - |
Camilo Zuniga | 6 | 4 | 6 | 2 | - | - |
Paolo Cannavaro | 4 | 2 | 15 | 2 | - | - |
Antonio Doblas | 2 | 1 | 9 | 1 | - | - |
Bruno Uvini | 1 | - | 14 | 1 | - | - |
Davide Bariti | 1 | - | 16 | 1 | - | - |
Roberto Colombo | 1 | - | 38 | 1 | - | - |
Nikita Contini | - | - | 4 | - | - | - | 524 | 418 | 362 | 106 | 106 | 76 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .