| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Samir Handanovic | 37 | 37 | - | - | - | - |
Mauro Icardi | 36 | 33 | 3 | 3 | 7 | 22 |
Gary Medel | 35 | 34 | 1 | 1 | 7 | - |
Rodrigo Palacio | 35 | 30 | 6 | 5 | 13 | 8 |
Mateo Kovacic | 35 | 26 | 11 | 9 | 10 | 5 |
Andrea Ranocchia | 33 | 32 | 4 | 1 | 3 | 2 |
Juan | 32 | 32 | - | - | 2 | - |
Fredy Guarin | 28 | 25 | 3 | 3 | 5 | 6 |
Hernanes | 26 | 17 | 16 | 9 | 6 | 5 |
Nemanja Vidic | 23 | 23 | 8 | - | 1 | 1 |
Danilo D'Ambrosio | 23 | 19 | 10 | 4 | 5 | - |
Dodo | 20 | 16 | 11 | 4 | 8 | - |
Lukas Podolski | 17 | 8 | 13 | 9 | 6 | 1 |
Marcelo Brozovic | 15 | 13 | 4 | 2 | 8 | 1 |
Xherdan Shaqiri | 15 | 8 | 12 | 7 | 5 | 1 |
Yuto Nagatomo | 14 | 11 | 10 | 3 | 2 | - |
Zdravko Kuzmanovic | 14 | 10 | 20 | 4 | 4 | - |
Dani Osvaldo | 12 | 5 | 7 | 7 | 1 | 5 |
Joel Obi | 11 | 6 | 31 | 5 | 5 | 1 |
Hugo Campagnaro | 10 | 8 | 14 | 2 | - | - |
Davide Santon | 9 | 7 | 8 | 2 | 1 | - |
Yann M'Vila | 8 | 3 | 10 | 5 | 2 | - |
Marco Andreolli | 6 | 5 | 26 | 1 | 1 | - |
Assane Demoya Gnoukouri | 5 | 2 | 8 | 3 | 2 | - |
Felipe | 4 | 3 | 11 | 1 | 2 | - |
George Puscas | 4 | 1 | 23 | 3 | 1 | - |
Federico Bonazzoli | 4 | - | 26 | 4 | - | - |
Ibrahima M'Baye | 4 | - | 15 | 4 | - | - |
Rene Krhin | 3 | - | 20 | 3 | - | - |
Jonathan | 2 | 2 | 1 | - | 1 | - |
Isaac Donkor | 2 | 1 | 14 | 1 | - | - |
Gaston Camara | 2 | - | 3 | 2 | - | - |
Juan Carrizo | 1 | 1 | 37 | - | - | - |
Federico Dimarco | 1 | - | 11 | 1 | - | - |
Andrea Palazzi | - | - | 1 | - | - | - |
Giacomo Sciacca | - | - | 2 | - | - | - |
Tommaso Berni | - | - | 22 | - | - | - |
Ze Turbo | - | - | 1 | - | - | - | 526 | 418 | 423 | 108 | 108 | 58 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .