| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Jose Callejon | 37 | 33 | 5 | 4 | 11 | 10 |
Gonzalo Higuain | 37 | 31 | 6 | 6 | 11 | 18 |
Raul Albiol | 35 | 34 | 2 | 1 | - | - |
Marek Hamsik | 35 | 28 | 9 | 7 | 18 | 8 |
David Lopez | 32 | 29 | 7 | 3 | 6 | 2 |
Dries Mertens | 31 | 17 | 18 | 14 | 12 | 6 |
Christian Maggio | 29 | 29 | 6 | - | 1 | - |
Kalidou Koulibaly | 27 | 27 | 7 | - | - | 1 |
Walter Gargano | 24 | 17 | 14 | 7 | 8 | - |
Jorginho | 24 | 14 | 20 | 10 | 5 | - |
Rafael Cabral | 23 | 23 | 14 | - | - | - |
Jonathan De Guzman | 23 | 12 | 18 | 11 | 7 | 3 |
Faouzi Ghoulam | 21 | 20 | 10 | 1 | 2 | - |
Duvan Zapata | 21 | 6 | 31 | 15 | 4 | 6 |
Lorenzo Insigne | 20 | 13 | 10 | 7 | 9 | 2 |
Manolo Gabbiadini | 20 | 8 | 13 | 12 | 7 | 8 |
Miguel Britos | 19 | 17 | 16 | 2 | 2 | 1 |
Gokhan Inler | 19 | 16 | 21 | 3 | 5 | 1 |
Mariano Andujar | 15 | 15 | 23 | - | - | - |
Henrique | 11 | 9 | 26 | 2 | - | - |
Ivan Strinic | 9 | 9 | 10 | - | 1 | - |
Camilo Zuniga | 7 | 6 | 7 | 1 | 1 | - |
Giandomencio Mesto | 7 | 3 | 28 | 4 | 1 | - |
Michu | 3 | 2 | 7 | 1 | 2 | - |
Josip Radosevic | 1 | - | 10 | 1 | - | - |
Sebastiano Luperto | 1 | - | 6 | 1 | - | - |
Roberto Colombo | - | - | 37 | - | - | - |
Bruno Uvini | - | - | 1 | - | - | - |
Nikita Contini | - | - | 2 | - | - | - | 531 | 418 | 384 | 113 | 113 | 66 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .