| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 David de Gea | 35 | 35 | - | - | - | - |
Marcus Rashford | 32 | 16 | 21 | 16 | 8 | 5 |
Ander Herrera | 31 | 27 | 7 | 4 | 5 | 1 |
Paul Pogba | 30 | 29 | 2 | 1 | 3 | 5 |
Zlatan Ibrahimovic | 28 | 27 | 1 | 1 | - | 17 |
Luis Antonio Valencia | 28 | 27 | 1 | 1 | 1 | 1 |
Marouane Fellaini | 28 | 18 | 14 | 10 | 4 | 1 |
Eric Bailly | 25 | 24 | 3 | 1 | 3 | - |
Juan Mata | 25 | 19 | 12 | 6 | 18 | 6 |
Jesse Lingard | 25 | 18 | 14 | 7 | 15 | 1 |
Anthony Martial | 25 | 18 | 13 | 7 | 11 | 4 |
Wayne Rooney | 25 | 15 | 13 | 10 | 9 | 5 |
Henrikh Mkhitaryan | 24 | 15 | 11 | 9 | 11 | 4 |
Daley Blind | 23 | 20 | 15 | 3 | 2 | 1 |
Michael Carrick | 23 | 18 | 15 | 5 | 4 | - |
Marcos Rojo | 21 | 18 | 6 | 3 | 1 | 1 |
Phil Jones | 18 | 18 | 1 | - | 1 | - |
Matteo Darmian | 18 | 15 | 11 | 3 | 3 | - |
Chris Smalling | 18 | 13 | 9 | 5 | 1 | 1 |
Ashley Young | 12 | 8 | 13 | 4 | 3 | - |
Luke Shaw | 11 | 9 | 6 | 2 | 5 | - |
Axel Tuanzebe | 4 | 4 | 5 | - | 2 | - |
Timothy Fosu-Mensah | 4 | 1 | 9 | 3 | - | - |
Memphis Depay | 4 | - | 5 | 4 | - | - |
Morgan Schneiderlin | 3 | - | 7 | 3 | - | - |
Sergio Romero | 2 | 2 | 35 | - | - | - |
Scott McTominay | 2 | 1 | 4 | 1 | - | - |
Joel Pereira | 1 | 1 | 2 | - | - | - |
Demetri Mitchell | 1 | 1 | 2 | - | - | - |
Josh Harrop | 1 | 1 | - | - | - | 1 |
Angel Gomes | 1 | - | 1 | 1 | - | - |
Bastian Schweinsteiger | - | - | 4 | - | - | - |
Matthew Willock | - | - | 2 | - | - | - |
Zachary Dearnley | - | - | 1 | - | - | - |
Kieran O'Hara | - | - | 1 | - | - | - | 528 | 418 | 266 | 110 | 110 | 54 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .