| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Samir Handanovic | 38 | 38 | - | - | - | - |
Matteo Politano | 36 | 31 | 5 | 5 | 23 | 5 |
Milan Skriniar | 35 | 35 | 3 | - | - | - |
Ivan Perisic | 34 | 30 | 8 | 4 | 8 | 8 |
Marcelo Brozovic | 32 | 31 | 1 | 1 | 7 | 2 |
Kwadwo Asamoah | 32 | 30 | 7 | 2 | 3 | - |
Danilo D'Ambrosio | 30 | 29 | 8 | 1 | 3 | 2 |
Matias Vecino | 30 | 23 | 12 | 7 | 9 | 3 |
Mauro Icardi | 29 | 24 | 8 | 5 | 6 | 11 |
Radja Nainggolan | 29 | 22 | 9 | 7 | 11 | 6 |
Stefan de Vrij | 28 | 28 | 5 | - | - | 2 |
Lautaro Martinez | 27 | 13 | 21 | 14 | 4 | 6 |
Borja Valero | 27 | 12 | 24 | 15 | 9 | - |
Keita Balde | 24 | 8 | 23 | 16 | 7 | 5 |
Joao Mario | 20 | 12 | 21 | 8 | 7 | 1 |
Roberto Gagliardini | 19 | 13 | 25 | 6 | 5 | 5 |
Antonio Candreva | 18 | 5 | 32 | 13 | 5 | 1 |
Joao Miranda | 14 | 14 | 20 | - | 3 | - |
Dalbert | 11 | 9 | 24 | 2 | 2 | - |
Sime Vrsaljko | 10 | 8 | 8 | 2 | 1 | - |
Cedric Soares | 4 | 3 | 14 | 1 | 1 | - |
Andrea Ranocchia | 4 | - | 38 | 4 | - | - |
Yann Karamoh | 1 | - | 2 | 1 | - | - |
Daniele Padelli | - | - | 38 | - | - | - |
Tommaso Berni | - | - | 1 | - | - | - | 532 | 418 | 357 | 114 | 114 | 57 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .