| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Jesus Navas | 38 | 37 | 1 | 1 | 2 | - |
Diego Carlos | 35 | 35 | 2 | - | 1 | 2 |
Luuk De Jong | 35 | 24 | 14 | 11 | 13 | 6 |
Joan Jordan | 34 | 27 | 7 | 7 | 17 | 2 |
Tomas Vaclik | 33 | 33 | - | - | 1 | - |
Lucas Ocampos | 33 | 31 | 2 | 2 | 12 | 14 |
Fernando | 33 | 30 | 4 | 3 | 3 | 2 |
Ever Banega | 33 | 28 | 7 | 5 | 12 | 3 |
Sergio Reguilon | 31 | 29 | 6 | 2 | 3 | 2 |
Franco Vazquez | 31 | 11 | 24 | 20 | 8 | 3 |
Jules Kounde | 29 | 25 | 12 | 4 | 1 | 1 |
Oliver Torres | 28 | 21 | 12 | 7 | 18 | 3 |
Nemanja Gudelj | 24 | 9 | 25 | 15 | - | - |
Munir El Haddadi | 21 | 14 | 15 | 7 | 9 | 5 |
Youssef En-Nesyri | 18 | 7 | 12 | 11 | 5 | 4 |
Suso | 17 | 8 | 9 | 9 | 6 | 1 |
Nolito | 15 | 12 | 9 | 3 | 9 | 3 |
Sergi Gomez | 13 | 8 | 13 | 5 | 2 | - |
Daniel Carrico | 11 | 10 | 2 | 1 | 3 | - |
Sergio Escudero | 11 | 8 | 23 | 3 | 2 | 1 |
Javier Hernandez | 9 | 4 | 11 | 5 | 3 | 1 |
Alex Bono | 6 | 5 | 28 | 1 | - | - |
Rony Lopes | 5 | 2 | 20 | 3 | 2 | - |
Alejandro Pozo | 3 | - | 4 | 3 | - | - |
Bryan Gil | 2 | - | 7 | 2 | - | - |
Munas Dabbur | 2 | - | 4 | 2 | - | - |
Sergio Rico | - | - | 3 | - | - | - |
Javier Diaz | - | - | 10 | - | - | - |
Jose Alonso Lara | - | - | 5 | - | - | - |
Felipe Chacartegui | - | - | 1 | - | - | - |
Pepe Mena | - | - | 8 | - | - | - |
Genaro Rodriguez | - | - | 10 | - | - | - |
Pablo Perez | - | - | 4 | - | - | - |
Juanlu Sanchez | - | - | 1 | - | - | - |
Alfonso Pastor | - | - | 4 | - | - | - | 550 | 418 | 319 | 132 | 132 | 53 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .