| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Romelu Lukaku | 36 | 33 | 3 | 3 | 8 | 23 |
Samir Handanovic | 35 | 35 | 3 | - | - | - |
Lautaro Martinez | 35 | 29 | 6 | 6 | 19 | 14 |
Stefan de Vrij | 34 | 32 | 5 | 2 | 2 | 4 |
Marcelo Brozovic | 32 | 30 | 3 | 2 | 4 | 3 |
Milan Skriniar | 32 | 30 | 4 | 2 | 2 | - |
Antonio Candreva | 32 | 24 | 12 | 8 | 16 | 5 |
Nicolo Barella | 27 | 23 | 5 | 4 | 6 | 1 |
Cristiano Biraghi | 26 | 18 | 18 | 8 | 9 | 2 |
Alessandro Bastoni | 25 | 21 | 15 | 4 | 3 | 2 |
Roberto Gagliardini | 24 | 21 | 7 | 3 | 10 | 4 |
Diego Godin | 23 | 18 | 18 | 5 | 6 | 1 |
Alexis Sanchez | 22 | 10 | 16 | 12 | 5 | 4 |
Danilo D'Ambrosio | 21 | 15 | 15 | 6 | 4 | 4 |
Matias Vecino | 20 | 14 | 9 | 6 | 4 | 2 |
Ashley Young | 18 | 13 | 5 | 5 | 6 | 4 |
Borja Valero | 18 | 8 | 28 | 10 | 4 | 2 |
Christian Eriksen | 17 | 8 | 9 | 9 | 5 | 1 |
Stefano Sensi | 12 | 9 | 6 | 3 | 7 | 3 |
Victor Moses | 12 | 4 | 10 | 8 | 4 | - |
Matteo Politano | 11 | 2 | 15 | 9 | 2 | - |
Kwadwo Asamoah | 8 | 7 | 16 | 1 | 1 | - |
Andrea Ranocchia | 7 | 5 | 32 | 2 | 1 | - |
Sebastiano Esposito | 7 | 2 | 31 | 5 | 1 | 1 |
Valentino Lazaro | 6 | 3 | 17 | 3 | 3 | - |
Daniele Padelli | 3 | 3 | 34 | - | - | - |
Lucien Agoume | 3 | - | 21 | 3 | - | - |
Federico Dimarco | 3 | - | 21 | 3 | - | - |
Zinho Vanheusden | 1 | 1 | - | - | - | - |
Lorenzo Pirola | 1 | - | 11 | 1 | - | - |
Tommaso Berni | - | - | 28 | - | - | - |
Sebastian Eriksson | - | - | - | - | 1 | - |
Dalbert | - | - | 1 | - | - | - | 551 | 418 | 424 | 133 | 133 | 80 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .