| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Papu Gomez | 36 | 34 | 3 | 2 | 20 | 7 |
Mario Pasalic | 35 | 30 | 7 | 5 | 14 | 9 |
Marten de Roon | 35 | 29 | 7 | 6 | 2 | 2 |
Berat Djimsiti | 34 | 32 | 5 | 2 | 8 | 2 |
Robin Gosens | 34 | 31 | 6 | 3 | 14 | 9 |
Ruslan Malinovskiy | 34 | 12 | 24 | 22 | 7 | 8 |
Luis Muriel | 34 | 10 | 25 | 24 | 9 | 18 |
Pierluigi Gollini | 33 | 33 | 5 | - | 1 | - |
Rafael Toloi | 33 | 29 | 6 | 4 | 2 | 2 |
Hans Hateboer | 32 | 25 | 11 | 7 | 3 | - |
Remo Freuler | 31 | 28 | 10 | 3 | 10 | 2 |
Jose Luis Palomino | 30 | 28 | 7 | 2 | 4 | 2 |
Duvan Zapata | 28 | 25 | 3 | 3 | 13 | 18 |
Timothy Castagne | 27 | 19 | 15 | 8 | 3 | 1 |
Josip Ilicic | 26 | 21 | 6 | 5 | 13 | 15 |
Mattia Caldara | 14 | 11 | 8 | 3 | 3 | - |
Andrea Masiello | 7 | 7 | 12 | - | 3 | - |
Bosko Sutalo | 7 | 3 | 10 | 4 | 2 | - |
Adrien Tameze-Aoutsa | 7 | 2 | 15 | 5 | - | - |
Musa Barrow | 7 | 1 | 17 | 6 | 1 | - |
Marco Sportiello | 6 | 5 | 31 | 1 | 1 | - |
Simon Kjaer | 5 | 3 | 9 | 2 | 1 | - |
Ebrima Colley | 5 | - | 18 | 5 | - | - |
Guilherme Arana | 4 | - | 14 | 4 | - | - |
Amad Diallo | 3 | - | 6 | 3 | - | 1 |
Francesco Rossi | 1 | - | 38 | 1 | - | - |
Jacopo Da Riva | 1 | - | 7 | 1 | - | - |
Lennart Czyborra | 1 | - | 16 | 1 | - | - |
Roberto Piccoli | 1 | - | 10 | 1 | - | - |
Raoul Bellanova | 1 | - | 16 | 1 | - | - |
Rodrigo Guth | - | - | 3 | - | - | - |
Martin Skrtel | - | - | 1 | - | - | - |
Roger Ibanez | - | - | 17 | - | - | - |
Khadim Ndiaye | - | - | 1 | - | - | - | 552 | 418 | 389 | 134 | 134 | 96 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .