| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Piotr Zielinski | 37 | 32 | 6 | 5 | 7 | 2 |
Lorenzo Insigne | 36 | 34 | 4 | 2 | 16 | 8 |
Giovanni Di Lorenzo | 33 | 33 | 4 | - | - | 3 |
Fabian | 33 | 30 | 7 | 3 | 8 | 3 |
Jose Callejon | 33 | 25 | 13 | 8 | 13 | 4 |
Dries Mertens | 31 | 18 | 15 | 13 | 10 | 9 |
Hirving Lozano | 27 | 10 | 25 | 17 | 9 | 4 |
Kostas Manolas | 26 | 25 | 7 | 1 | 3 | 4 |
Arkadiusz Milik | 26 | 19 | 10 | 7 | 11 | 11 |
Elif Elmas | 26 | 12 | 25 | 14 | 8 | 1 |
Kalidou Koulibaly | 25 | 24 | 3 | 1 | 2 | - |
Mario Rui | 24 | 22 | 11 | 2 | 4 | - |
Allan | 23 | 16 | 12 | 7 | 8 | 2 |
Alex Meret | 22 | 21 | 15 | 1 | - | - |
Nikola Maksimovic | 22 | 20 | 11 | 2 | 2 | 1 |
Elseid Hysaj | 20 | 17 | 17 | 3 | 6 | 1 |
David Ospina | 17 | 17 | 18 | - | 1 | - |
Fernando Llorente | 17 | 3 | 20 | 14 | 2 | 3 |
Diego Demme | 15 | 10 | 8 | 5 | 7 | 1 |
Matteo Politano | 15 | 9 | 8 | 6 | 8 | 2 |
Stanislav Lobotka | 14 | 9 | 10 | 5 | 6 | - |
Sebastiano Luperto | 9 | 5 | 32 | 4 | 1 | - |
Faouzi Ghoulam | 9 | 3 | 21 | 6 | 1 | - |
Amin Younes | 9 | 1 | 27 | 8 | 1 | 1 |
Kevin Malcuit | 4 | 3 | 9 | 1 | 1 | - |
Leandrinho | - | - | 5 | - | - | - |
Hubert Dawid Idasiak | - | - | 1 | - | - | - |
Antonio Pio Daniele | - | - | 3 | - | - | - |
Lorenzo Tonelli | - | - | 9 | - | - | - |
Vlad Chiriches | - | - | 1 | - | - | - |
Simone Verdi | - | - | 2 | - | - | - |
Orestis Karnezis | - | - | 33 | - | - | - |
Gianluca Gaetano | - | - | 18 | - | - | - | 553 | 418 | 410 | 135 | 135 | 60 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .