| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Bruno Fernandes | 37 | 35 | 2 | 2 | 12 | 18 |
Marcus Rashford | 37 | 33 | 5 | 4 | 11 | 11 |
Harry Maguire | 34 | 34 | - | - | 1 | 2 |
Aaron Wan-Bissaka | 34 | 34 | 3 | - | - | 2 |
Luke Shaw | 32 | 30 | 4 | 2 | 3 | 1 |
Scott McTominay | 32 | 24 | 12 | 8 | 4 | 4 |
Mason Greenwood | 31 | 21 | 14 | 10 | 14 | 7 |
Fred | 30 | 27 | 8 | 3 | 9 | 1 |
Victor Lindelof | 29 | 29 | 5 | - | 1 | 1 |
David de Gea | 26 | 26 | 7 | - | 1 | - |
Paul Pogba | 26 | 21 | 8 | 5 | 4 | 3 |
Edinson Cavani | 26 | 13 | 13 | 13 | 5 | 10 |
Anthony Martial | 22 | 17 | 6 | 5 | 11 | 4 |
Nemanja Matic | 20 | 12 | 25 | 8 | 1 | - |
Donny van de Beek | 19 | 4 | 30 | 15 | 1 | 1 |
Dan James | 15 | 11 | 16 | 4 | 7 | 3 |
Dean Henderson | 13 | 12 | 26 | 1 | - | - |
Eric Bailly | 12 | 10 | 16 | 2 | 1 | - |
Alex Telles | 9 | 8 | 23 | 1 | 3 | - |
Juan Mata | 9 | 6 | 20 | 3 | 5 | 1 |
Axel Tuanzebe | 9 | 4 | 26 | 5 | 1 | - |
Brandon Williams | 4 | 2 | 18 | 2 | - | - |
Amad Diallo | 3 | 2 | 9 | 1 | 2 | - |
Anthony Elanga | 2 | 2 | - | - | 1 | 1 |
Shola Shoretire | 2 | - | 5 | 2 | - | - |
Timothy Fosu-Mensah | 1 | 1 | 2 | - | 1 | - |
Will Fish | 1 | - | 1 | 1 | - | - |
Hannibal Mejbri | 1 | - | 1 | 1 | - | - |
Odion Ighalo | 1 | - | 2 | 1 | - | - |
Jesse Lingard | - | - | 4 | - | - | - |
Lee Grant | - | - | 5 | - | - | - |
Nathan Bishop | - | - | 1 | - | - | - | 517 | 418 | 317 | 99 | 99 | 70 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .