| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Matteo Politano | 37 | 22 | 16 | 15 | 18 | 9 |
Giovanni Di Lorenzo | 36 | 36 | - | - | - | 3 |
Piotr Zielinski | 36 | 32 | 4 | 4 | 28 | 7 |
Lorenzo Insigne | 35 | 33 | 2 | 2 | 11 | 19 |
Fabian | 33 | 29 | 5 | 4 | 11 | 3 |
Elif Elmas | 33 | 3 | 33 | 30 | 2 | 2 |
Tiemoue Bakayoko | 32 | 23 | 12 | 9 | 14 | 2 |
Hirving Lozano | 32 | 23 | 9 | 9 | 14 | 11 |
Kostas Manolas | 30 | 27 | 6 | 3 | 6 | - |
Dries Mertens | 29 | 18 | 11 | 11 | 17 | 9 |
Mario Rui | 27 | 17 | 20 | 10 | 5 | - |
Kalidou Koulibaly | 26 | 25 | 2 | 1 | 2 | - |
Andrea Petagna | 26 | 9 | 23 | 17 | 7 | 4 |
Elseid Hysaj | 24 | 20 | 12 | 4 | 7 | - |
Diego Demme | 24 | 20 | 13 | 4 | 10 | 2 |
Victor Osimhen | 24 | 16 | 9 | 8 | 10 | 11 |
Alex Meret | 21 | 21 | 17 | - | - | - |
David Ospina | 17 | 17 | 16 | - | - | - |
Nikola Maksimovic | 17 | 12 | 22 | 5 | 3 | - |
Amir Rrahmani | 16 | 12 | 20 | 4 | 1 | 1 |
Stanislav Lobotka | 15 | - | 33 | 15 | - | - |
Faouzi Ghoulam | 11 | 3 | 19 | 8 | 2 | - |
Fernando Llorente | 3 | - | 11 | 3 | - | - |
Kevin Malcuit | 2 | - | 9 | 2 | - | - |
Antonio Cioffi | 1 | - | 20 | 1 | - | - |
Hubert Dawid Idasiak | - | - | 5 | - | - | - |
Sebastiano Luperto | - | - | 2 | - | - | - |
Nikita Contini | - | - | 38 | - | - | - |
Karim Zedadka | - | - | 14 | - | 1 | - |
Davide Costanzo | - | - | 10 | - | - | - |
Giuseppe D'Agostino | - | - | 8 | - | - | - |
Valerio Labriola | - | - | 5 | - | - | - | 587 | 418 | 426 | 169 | 169 | 83 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .