| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Elif Elmas | 37 | 12 | 25 | 25 | 6 | 3 |
Piotr Zielinski | 35 | 26 | 10 | 9 | 19 | 6 |
Mario Rui | 34 | 34 | 1 | - | 11 | - |
Amir Rrahmani | 33 | 33 | 4 | - | 1 | 4 |
Giovanni Di Lorenzo | 33 | 33 | 1 | - | 4 | 1 |
Matteo Politano | 33 | 20 | 15 | 13 | 19 | 3 |
Fabian | 32 | 29 | 4 | 3 | 17 | 7 |
Lorenzo Insigne | 32 | 28 | 5 | 4 | 24 | 11 |
David Ospina | 31 | 31 | 5 | - | 1 | - |
Hirving Lozano | 30 | 20 | 11 | 10 | 19 | 5 |
Dries Mertens | 30 | 16 | 17 | 14 | 13 | 11 |
Kalidou Koulibaly | 27 | 27 | - | - | 1 | 3 |
Victor Osimhen | 27 | 23 | 4 | 4 | 12 | 14 |
Frank Anguissa | 25 | 21 | 4 | 4 | 3 | - |
Andrea Petagna | 24 | 4 | 31 | 20 | 4 | 3 |
Stanislav Lobotka | 23 | 19 | 10 | 4 | 6 | 1 |
Juan | 21 | 14 | 24 | 7 | 1 | 1 |
Diego Demme | 19 | 7 | 23 | 12 | 6 | 1 |
Adam Ounas | 15 | 1 | 20 | 14 | - | - |
Faouzi Ghoulam | 14 | 3 | 26 | 11 | 1 | - |
Alessandro Zanoli | 12 | 5 | 28 | 7 | 1 | - |
Kevin Malcuit | 8 | 2 | 24 | 6 | 2 | - |
Alex Meret | 7 | 7 | 25 | - | 1 | - |
Kostas Manolas | 4 | 3 | 6 | 1 | - | - |
Gianluca Gaetano | 2 | - | 2 | 2 | - | - |
Davide Marfella | 1 | - | 35 | 1 | - | - |
Axel Tuanzebe | 1 | - | 10 | 1 | - | - |
Moussa Mane | - | - | 1 | - | - | - |
Antonio Vergara | - | - | 2 | - | - | - |
Davide Costanzo | - | - | 2 | - | - | - |
Jonathan Spedalieri | - | - | 1 | - | - | - |
Giuseppe Ambrosino | - | - | 1 | - | - | - |
Antonio Cioffi | - | - | 1 | - | - | - |
Hubert Dawid Idasiak | - | - | 8 | - | - | - |
Luca Palmiero | - | - | 2 | - | - | - |
Benedetto Barba | - | - | 1 | - | - | - | 590 | 418 | 389 | 172 | 172 | 74 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .