| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Andre Onana | 36 | 36 | - | - | - | - |
Diogo Dalot | 34 | 33 | 2 | 1 | - | 1 |
Alejandro Garnacho | 34 | 28 | 8 | 6 | 17 | 7 |
Bruno Fernandes | 33 | 33 | - | - | - | 10 |
Marcus Rashford | 31 | 26 | 5 | 5 | 14 | 7 |
Scott McTominay | 30 | 16 | 16 | 14 | 3 | 7 |
Antony | 29 | 15 | 16 | 14 | 12 | 1 |
Rasmus Hojlund | 28 | 25 | 3 | 3 | 16 | 8 |
Casemiro | 23 | 22 | 2 | 1 | 6 | 1 |
Kobbie Mainoo | 22 | 22 | 5 | - | 15 | 2 |
Harry Maguire | 22 | 18 | 7 | 4 | 1 | 2 |
Raphael Varane | 21 | 16 | 9 | 5 | 4 | 1 |
Jonny Evans | 21 | 14 | 10 | 7 | 7 | - |
Aaron Wan-Bissaka | 20 | 18 | 5 | 2 | 4 | - |
Christian Eriksen | 20 | 12 | 19 | 8 | 7 | 1 |
Victor Lindelof | 19 | 14 | 7 | 5 | 7 | 1 |
Sofyan Amrabat | 19 | 8 | 19 | 11 | 3 | - |
Mason Mount | 14 | 5 | 9 | 9 | 5 | 1 |
Anthony Martial | 13 | 5 | 11 | 8 | 5 | 1 |
Luke Shaw | 12 | 12 | - | - | 5 | - |
Lisandro Martinez | 9 | 7 | 2 | 2 | 5 | - |
Sergio Reguilon | 9 | 4 | 10 | 5 | 3 | - |
Facundo Pellistri | 9 | 1 | 19 | 8 | 1 | - |
Willy Kambwala | 8 | 3 | 11 | 5 | 1 | - |
Amad Diallo | 7 | 1 | 14 | 6 | 1 | - |
Hannibal Mejbri | 5 | 1 | 12 | 4 | - | 1 |
Omari Forson | 4 | 1 | 11 | 3 | 1 | - |
Jadon Sancho | 3 | - | 3 | 3 | - | - |
Ethan Wheatley | 2 | - | 5 | 2 | - | - |
Donny van de Beek | 1 | - | 12 | 1 | - | - |
Daniel Gore | 1 | - | 7 | 1 | - | - |
Tom Heaton | - | - | 4 | - | - | - |
Rhys Bennett | - | - | 1 | - | - | - |
Toby Collyer | - | - | 5 | - | - | - |
Dean Henderson | - | - | 3 | - | - | - |
Altay Bayindir | - | - | 31 | - | - | - |
Dermot Mee | - | - | 1 | - | - | - |
Habeeb Ogunneye | - | - | 7 | - | - | - |
Alvaro Fernandez | - | - | 1 | - | - | - |
Harry Amass | - | - | 6 | - | - | - |
Radek Vitek | - | - | 1 | - | - | - |
Louis Jackson | - | - | 3 | - | - | - | 539 | 396 | 322 | 143 | 143 | 52 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .