| Group D | P | W | D | L | GF | GA | GD | points |
|---|---|---|---|---|---|---|---|---|
 Valencia | 6 | 4 | 1 | 1 | 12 | 6 | 6 | 13 |
 AS Roma | 6 | 3 | 1 | 2 | 8 | 4 | 4 | 10 |
 Shakhtar Donetsk | 6 | 1 | 3 | 2 | 6 | 11 | -5 | 6 |
Olympiakos | 6 | 0 | 3 | 3 | 6 | 11 | -5 | 3 |
Tuesday 5 December 2006 | |||||||
| AS Roma | 1 | - | 0 | Valencia | 18:45 | STATS» | |
| Olympiakos | 1 | - | 1 | Shakhtar Donetsk | 18:45 | STATS» | |
Wednesday 22 November 2006 | |||||||
| Shakhtar Donetsk | 1 | - | 0 | AS Roma | 18:45 | STATS» | |
| Valencia | 2 | - | 0 | Olympiakos | 18:45 | STATS» | |
Tuesday 31 October 2006 | |||||||
| AS Roma | 1 | - | 1 | Olympiakos | 19:45 | STATS» | |
| Shakhtar Donetsk | 2 | - | 2 | Valencia | 19:45 | STATS» | |
Wednesday 18 October 2006 | |||||||
| Olympiakos | 0 | - | 1 | AS Roma | 18:45 | STATS» | |
| Valencia | 2 | - | 0 | Shakhtar Donetsk | 18:45 | STATS» | |
Wednesday 27 September 2006 | |||||||
| Valencia | 2 | - | 1 | AS Roma | 19:45 | STATS» | |
| Shakhtar Donetsk | 2 | - | 2 | Olympiakos | 19:45 | STATS» | |
Tuesday 12 September 2006 | |||||||
| AS Roma | 4 | - | 0 | Shakhtar Donetsk | 19:45 | STATS» | |
| Olympiakos | 2 | - | 4 | Valencia | 19:45 | STATS» | |