| Yellow | Clubs | VS Club | Date | Sections | |
|---|---|---|---|---|---|
| 8 | Olympique Lyonnais | Sparta Prague | 21-10-2021 | Group Stage | Match details |
| 8 | Spartak Moscow | Napoli | 30-09-2021 | Group Stage | Match details |
| 6 | Atalanta | RB Leipzig | 14-04-2022 | Quarter-finals | Match details |
| 6 | Eintracht Frankfurt | Barcelona | 14-04-2022 | Quarter-finals | Match details |
| 6 | FC Sheriff Tiraspol | Sporting Braga | 24-02-2022 | Knockout Play offs | Match details |
| 5 | Eintracht Frankfurt | West Ham United | 05-05-2022 | Semi-finals | Match details |
| 5 | Red Star Belgrade | Ludogorets Razgrad | 30-09-2021 | Group Stage | Match details |
| 5 | FC Midtylland | Sporting Braga | 30-09-2021 | Group Stage | Match details |
| 5 | Rapid Wien | KRC Genk | 16-09-2021 | Group Stage | Match details |
| 5 | Real Sociedad | PSV Eindhoven | 16-09-2021 | Group Stage | Match details |
