| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Hugo Lloris | Olympique Lyonnais | France | 17 | |
| 2 | Franco Costanzo | FC Basel | Argentina | 16 | |
| 3 | Karim Zaza | Aalborg BK | Morocco | 16 | |
| 4 | Rui Patricio | Sporting Lisbon | Portugal | 16 | |
| 5 | Andreas Isaksson | PSV Eindhoven | Sweden | 14 | |
| 6 | Petr Cech | Chelsea | Czech Republic | 13 | |
| 7 | Helton | FC Porto | Brazil | 12 | |
| 8 | Volkan Demirel | Fenerbahce | Turkey | 12 | |
| 9 | Robinson Zapata | Steaua Bucharest | Colombia | 11 | |
| 10 | Pepe Reina | Liverpool | Spain | 11 | |
| 11 | Iker Casillas | Real Madrid | Spain | 11 | |
| 12 | Diego Lopez | Villarreal | Spain | 11 | |
| 13 | Victor Valdes | Barcelona | Spain | 11 | |
| 14 | Manuel Almunia | Arsenal | Spain | 11 | |
| 15 | Julio Cesar | Internazionale | Brazil | 9 | |
| 16 | Sergei Veremko | FC BATE Borisov | Belarus | 8 | |
| 17 | Mario Galinovic | Panathinaikos | Croatia | 8 | |
| 18 | Viacheslav Malafeev | Zenit St Petersburg | Russia | 7 | |
| 19 | Sebastian Frey | Fiorentina | France | 7 | |
| 20 | Hans-Jorg Butt | Bayern Munich | Germany | 7 |
GC = Goals conceded