| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Sebastian Frey | Genoa | France | 70 | |
| 2 | Francesco Antonioli | AC Cesena | Italy | 49 | |
| 3 | Antonio Mirante | Parma | Italy | 48 | |
| 4 | Morgan De Sanctis | Napoli | Italy | 47 | |
| 5 | Michael Agazzi | Cagliari | Italy | 46 | |
| 6 | Maarten Stekelenburg | AS Roma | Netherlands | 45 | |
| 7 | Julio Cesar | Internazionale | Brazil | 45 | |
| 8 | Artur Boruc | Fiorentina | Poland | 42 | |
| 9 | Samir Ujkani | Novara Calcio | Kosovo | 42 | |
| 10 | Stefano Sorrentino | Chievo | Italy | 41 | |
| 11 | Emiliano Viviano | Palermo | Italy | 39 | |
| 12 | Massimiliano Benassi | Lecce | Italy | 39 | |
| 13 | Andrea Consigli | Atalanta | Italy | 39 | |
| 14 | Federico Marchetti | SS Lazio | Italy | 37 | |
| 15 | Jean Francois Gillet | Bologna | Belgium | 36 | |
| 16 | Samir Handanovic | Udinese | Slovenia | 36 | |
| 17 | Christian Abbiati | AC Milan | Italy | 30 | |
| 18 | Mariano Andujar | Catania | Argentina | 23 | |
| 19 | Gianluca Pegolo | Siena | Italy | 23 | |
| 20 | Alberto Fontana | Novara Calcio | Italy | 22 |
GC = Goals conceded