| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Dan Kennedy | Chivas USA | United States | 59 | |
| 2 | Troy Perkins | Montreal Impact | United States | 48 | |
| 3 | Joe Bendik | Toronto FC | United States | 45 | |
| 4 | Raul Fernandez | FC Dallas | Peru | 43 | |
| 5 | Luis Robles | New York Red Bulls | United States | 42 | |
| 6 | Jon Busch | San Jose Earthquakes | United States | 42 | |
| 7 | Zac MacMath | Philadelphia Union | United States | 42 | |
| 8 | Sean Johnson | Chicago Fire | United States | 41 | |
| 9 | Bill Hamid | DC United | United States | 40 | |
| 10 | Tally Hall | Houston Dynamo | United States | 39 | |
| 11 | Michael Gspurning | Seattle Sounders | Austria | 38 | |
| 12 | Clint Irwin | Colorado Rapids | United States | 36 | |
| 13 | Donovan Ricketts | Portland Timbers | Jamaica | 32 | |
| 14 | Jimmy Nielsen | Sporting Kansas City | Denmark | 32 | |
| 15 | Nick Rimando | Real Salt Lake | United States | 29 | |
| 16 | Bobby Shuttleworth | New England Revolution | United States | 28 | |
| 17 | Carlo Cudicini | Los Angeles Galaxy | Italy | 28 | |
| 18 | Andy Gruenebaum | Columbus Crew | United States | 27 | |
| 19 | Joe Willis | DC United | United States | 20 | |
| 20 | Matt Lampson | Columbus Crew | United States | 19 |
GC = Goals conceded