| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Dan Kennedy | Chivas USA | United States | 58 | |
| 2 | Jon Busch | San Jose Earthquakes | United States | 51 | |
| 3 | Stefan Frei | Seattle Sounders | Switzerland | 51 | |
| 4 | Luis Robles | New York Red Bulls | United States | 50 | |
| 5 | Sean Johnson | Chicago Fire | United States | 49 | |
| 6 | Donovan Ricketts | Portland Timbers | Jamaica | 47 | |
| 7 | Zac MacMath | Philadelphia Union | United States | 46 | |
| 8 | Joe Bendik | Toronto FC | United States | 46 | |
| 9 | Tally Hall | Houston Dynamo | United States | 45 | |
| 10 | Clint Irwin | Colorado Rapids | United States | 44 | |
| 11 | Bobby Shuttleworth | New England Revolution | United States | 43 | |
| 12 | Steve Clark | Columbus Crew | United States | 43 | |
| 13 | David Ousted | Vancouver Whitecaps | Denmark | 41 | |
| 14 | Bill Hamid | DC United | United States | 37 | |
| 15 | Troy Perkins | Montreal Impact | United States | 35 | |
| 16 | Jaime Penedo | Los Angeles Galaxy | Panama | 34 | |
| 17 | Nick Rimando | Real Salt Lake | United States | 27 | |
| 18 | Raul Fernandez | FC Dallas | Peru | 25 | |
| 19 | Evan Bush | Montreal Impact | United States | 23 | |
| 20 | Eric Kronberg | Sporting Kansas City | United States | 23 |
GC = Goals conceded