| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Josh Saunders | New York City | United States | 58 | |
| 2 | Steve Clark | Columbus Crew | United States | 54 | |
| 3 | Tally Hall | Orlando City | United States | 45 | |
| 4 | Tyler Deric | Houston Dynamo | United States | 44 | |
| 5 | Luis Robles | New York Red Bulls | United States | 43 | |
| 6 | Bobby Shuttleworth | New England Revolution | United States | 42 | |
| 7 | David Bingham | San Jose Earthquakes | United States | 39 | |
| 8 | Evan Bush | Montreal Impact | United States | 39 | |
| 9 | Clint Irwin | Colorado Rapids | United States | 38 | |
| 10 | Adam Larsen Kwarasey | Portland Timbers | Ghana | 36 | |
| 11 | David Ousted | Vancouver Whitecaps | Denmark | 36 | |
| 12 | Stefan Frei | Seattle Sounders | Switzerland | 33 | |
| 13 | Donovan Ricketts | Orlando City | Jamaica | 33 | |
| 14 | Chris Konopka | Toronto FC | United States | 32 | |
| 15 | Sean Johnson | Chicago Fire | United States | 32 | |
| 16 | Bill Hamid | DC United | United States | 29 | |
| 17 | Tim Melia | Sporting Kansas City | United States | 29 | |
| 18 | Joe Bendik | Toronto FC | United States | 27 | |
| 19 | Nick Rimando | Real Salt Lake | United States | 25 | |
| 20 | Jeff Attinella | Real Salt Lake | United States | 24 |
GC = Goals conceded