| Players | Clubs | Position | Total | Goals | A |  |
 |
 |
Start | Sub | CO | Off | Pen S | Pen SV | Pen M | Pen C | OG | More |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Wayne Rooney | Manchester United | Forward | 12 | 4 | 0 | 1 | 0 | 0 | 12 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | |
| Michael Carrick | Manchester United | Midfielder | 12 | 2 | 0 | 1 | 0 | 0 | 12 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | |
| Edwin van der Sar | Manchester United | Goalkeeper | 12 | 0 | 0 | 0 | 0 | 0 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Cristiano Ronaldo | Manchester United | Forward | 11 | 3 | 3 | 3 | 0 | 0 | 11 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | |
| Paul Scholes | Manchester United | Midfielder | 11 | 1 | 1 | 3 | 1 | 0 | 10 | 1 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | |
| John O'Shea | Manchester United | Defender | 11 | 1 | 0 | 0 | 0 | 0 | 8 | 4 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | |
| Rio Ferdinand | Manchester United | Defender | 9 | 0 | 0 | 1 | 0 | 0 | 8 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Darren Fletcher | Manchester United | Midfielder | 9 | 0 | 0 | 1 | 0 | 0 | 6 | 5 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | |
| Ryan Giggs | Manchester United | Midfielder | 8 | 2 | 5 | 1 | 0 | 0 | 8 | 2 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | |
| Nemanja Vidic | Manchester United | Defender | 8 | 1 | 0 | 1 | 0 | 0 | 8 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | |
| Gabriel Heinze | Manchester United | Defender | 8 | 0 | 0 | 2 | 0 | 0 | 7 | 2 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | |
| Louis Saha | Manchester United | Forward | 8 | 4 | 1 | 0 | 0 | 0 | 5 | 3 | 3 | 2 | 1 | 0 | 1 | 0 | 0 | |
| Wes Brown | Manchester United | Defender | 7 | 0 | 0 | 0 | 0 | 0 | 7 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Patrice Evra | Manchester United | Defender | 7 | 1 | 0 | 3 | 0 | 0 | 4 | 5 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | |
| Gary Neville | Manchester United | Defender | 6 | 0 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Ole-Gunnar Solskjaer | Manchester United | Forward | 6 | 1 | 1 | 1 | 0 | 0 | 2 | 7 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | |
| Alan Smith | Manchester United | Forward | 4 | 1 | 0 | 1 | 0 | 0 | 1 | 8 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Kieran Richardson | Manchester United | Midfielder | 4 | 1 | 0 | 1 | 0 | 0 | 0 | 10 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Mikael Silvestre | Manchester United | Defender | 3 | 0 | 0 | 1 | 0 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Henrik Larsson | Manchester United | Forward | 2 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | |
| Ji Sung Park | Manchester United | Midfielder | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| David Jones | Manchester United | Midfielder | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Craig Cathcart | Manchester United | Defender | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Chris Eagles | Manchester United | Midfielder | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| FangZhou Dong | Manchester United | Forward | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Kieran Lee | Manchester United | Defender | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Tomasz Kuszczak | Manchester United | Goalkeeper | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A = Assists,
CS = Clean sheets Full
Sub = Started as a sub,
CO = Came on,
Off = Taken off,
S = Scored,
M = Missed,
Total = Total appearances,
OG = Own goals.