| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Michael Carrick | 12 | 12 | - | - | 3 | 2 |
Wayne Rooney | 12 | 12 | - | - | 3 | 4 |
Edwin van der Sar | 12 | 12 | - | - | - | - |
Cristiano Ronaldo | 11 | 11 | - | - | 2 | 3 |
Paul Scholes | 11 | 10 | 1 | 1 | 4 | 1 |
John O'Shea | 11 | 8 | 4 | 3 | 2 | 1 |
Rio Ferdinand | 9 | 8 | 2 | 1 | - | - |
Darren Fletcher | 9 | 6 | 5 | 3 | 1 | - |
Ryan Giggs | 8 | 8 | 2 | - | 4 | 2 |
Nemanja Vidic | 8 | 8 | 1 | - | 1 | 1 |
Gabriel Heinze | 8 | 7 | 2 | 1 | 2 | - |
Louis Saha | 8 | 5 | 3 | 3 | 2 | 4 |
Wes Brown | 7 | 7 | 5 | - | - | - |
Patrice Evra | 7 | 4 | 5 | 3 | 1 | 1 |
Gary Neville | 6 | 6 | - | - | - | - |
Ole-Gunnar Solskjaer | 6 | 2 | 7 | 4 | 1 | 1 |
Alan Smith | 4 | 1 | 8 | 3 | - | 1 |
Kieran Richardson | 4 | - | 10 | 4 | - | 1 |
Mikael Silvestre | 3 | 3 | 3 | - | - | - |
Henrik Larsson | 2 | 2 | - | - | 1 | 1 |
Ji Sung Park | 1 | - | 2 | 1 | - | - |
David Jones | - | - | 2 | - | - | - |
Chris Eagles | - | - | 4 | - | - | - |
Tomasz Kuszczak | - | - | 12 | - | - | - |
FangZhou Dong | - | - | 3 | - | - | - |
Kieran Lee | - | - | 1 | - | - | - |
Craig Cathcart | - | - | 1 | - | - | - | 159 | 132 | 83 | 27 | 27 | 23 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .