| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Richard Dunne | 38 | 38 | - | - | - | 1 |
Sylvain Distin | 37 | 37 | - | - | 2 | 2 |
Georgios Samaras | 36 | 16 | 22 | 20 | 10 | 4 |
Joey Barton | 33 | 33 | - | - | - | 6 |
Darius Vassell | 32 | 28 | 4 | 4 | 11 | 3 |
Micah Richards | 28 | 28 | - | - | 5 | 1 |
Nicky Weaver | 25 | 25 | 10 | - | 2 | - |
Bernardo Corradi | 25 | 19 | 10 | 6 | 8 | 3 |
Stephen Ireland | 24 | 14 | 13 | 10 | 5 | 1 |
Hatem Trabelsi | 20 | 16 | 8 | 4 | 7 | 1 |
Nedum Onuoha | 18 | 15 | 7 | 3 | 4 | - |
Trevor Sinclair | 18 | 14 | 4 | 4 | 1 | - |
DaMarcus Beasley | 18 | 11 | 12 | 7 | 6 | 3 |
Dietmar Hamann | 16 | 12 | 9 | 4 | 8 | - |
Paul Dickov | 16 | 9 | 14 | 7 | 7 | - |
Ishmael Miller | 16 | 3 | 17 | 13 | 3 | - |
Claudio Reyna | 15 | 12 | 4 | 3 | 8 | - |
Andreas Isaksson | 14 | 12 | 11 | 2 | - | - |
Stephen Jordan | 13 | 12 | 2 | 1 | 1 | - |
Sun Jihai | 13 | 10 | 4 | 3 | 4 | - |
Ousmane Dabo | 13 | 10 | 8 | 3 | 2 | - |
Michael Ball | 12 | 12 | - | - | 1 | - |
Ben Thatcher | 11 | 11 | 1 | - | 1 | - |
Michael Johnson | 10 | 10 | 3 | - | - | - |
Emile Mpenza | 10 | 9 | 1 | 1 | 1 | 3 |
Daniel Sturridge | 2 | - | 2 | 2 | - | - |
Matthew Mills | 1 | 1 | 2 | - | 1 | - |
Joe Hart | 1 | 1 | 16 | - | - | - |
Danny Mills | 1 | - | 3 | 1 | - | - |
Marc Laird | - | - | 2 | - | - | - |
Kasper Schmeichel | - | - | 1 | - | - | - | 516 | 418 | 190 | 98 | 98 | 28 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .