| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Manu Trigueros | 35 | 27 | 9 | 8 | 21 | 6 |
Pau Torres | 33 | 33 | 1 | - | 3 | 5 |
Daniel Parejo | 33 | 32 | 2 | 1 | 9 | 2 |
Geronimo Rulli | 32 | 32 | 6 | - | - | - |
Yeremi Pino | 31 | 21 | 12 | 10 | 19 | 6 |
Etienne Capoue | 30 | 26 | 7 | 4 | 11 | 1 |
Moises Gomez | 29 | 13 | 24 | 16 | 9 | 2 |
Raul Albiol | 28 | 28 | 6 | - | 2 | - |
Alfonso Pedraza | 28 | 19 | 18 | 9 | 11 | 4 |
Pervis Estupinan | 28 | 17 | 20 | 11 | 10 | - |
Samuel Chukwueze | 27 | 12 | 15 | 15 | 9 | 3 |
Juan Foyth | 25 | 22 | 8 | 3 | 9 | 1 |
Boulaye Dia | 25 | 13 | 16 | 12 | 10 | 5 |
Alberto Moreno | 24 | 13 | 14 | 11 | 10 | 3 |
Arnaut Danjuma | 23 | 17 | 6 | 6 | 11 | 10 |
Vicente Iborra | 20 | 12 | 26 | 8 | 4 | - |
Francis Coquelin | 20 | 8 | 13 | 12 | 7 | 2 |
Serge Aurier | 19 | 10 | 11 | 9 | 2 | - |
Paco Alcacer | 18 | 10 | 16 | 8 | 10 | 1 |
Aissa Mandi | 17 | 14 | 22 | 3 | - | 1 |
Gerard Moreno | 17 | 14 | 4 | 3 | 5 | 9 |
Giovani Lo Celso | 16 | 11 | 5 | 5 | 7 | 1 |
Mario Gaspar | 12 | 7 | 31 | 5 | 3 | - |
Nicolas Jackson | 9 | - | 11 | 9 | - | - |
Ruben Pena | 7 | 1 | 24 | 6 | 1 | - |
Daniel Raba | 7 | - | 17 | 7 | - | - |
Sergio Asenjo | 6 | 6 | 30 | - | - | - |
Nikita Iosifov | 1 | - | 6 | 1 | - | - |
Carlo Garcia | 1 | - | 3 | 1 | - | - |
Adrian de la Fuente | - | - | 2 | - | - | - |
Iker Alvarez | - | - | 10 | - | - | - |
Filip Jorgensen | - | - | 14 | - | - | - |
Juan Carlos Arana | - | - | 1 | - | - | - |
Jorge Cuenca | - | - | 3 | - | - | - |
Antonio Pacheco | - | - | 2 | - | - | - |
Lanchi | - | - | 1 | - | - | - | 601 | 418 | 416 | 183 | 183 | 62 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .