| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Luis Maximiano | UD Almeria | Portugal | 58 | |
| 2 | Filip Jorgensen | Villarreal | Sweden | 55 | |
| 3 | Jeremias Ledesma | Cadiz CF | Argentina | 45 | |
| 4 | David Soria | Getafe | Spain | 45 | |
| 5 | Stole Dimitrievski | Rayo Vallecano | North Macedonia | 42 | |
| 6 | Sergio Herrera | Osasuna | Spain | 42 | |
| 7 | Jan Oblak | Atletico Madrid | Slovenia | 41 | |
| 8 | Antonio Sivera | CD Alaves | Spain | 41 | |
| 9 | Paulo Gazzaniga | Girona FC | Argentina | 40 | |
| 10 | Predrag Rajkovic | RCD Mallorca | Serbia | 39 | |
| 11 | Alvaro Valles | Las Palmas | Spain | 39 | |
| 12 | Giorgi Mamardashvili | Valencia | Georgia | 38 | |
| 13 | Alejandro Remiro | Real Sociedad | Spain | 35 | |
| 14 | Rui Silva | Real Betis | Portugal | 34 | |
| 15 | Unai Simon | Athletic Bilbao | Spain | 33 | |
| 16 | Vicente Guaita | Celta Vigo | Spain | 31 | |
| 17 | Andre Ferreira | Granada CF | Brazil | 28 | |
| 18 | Marko Dmitrovic | Sevilla | Serbia | 26 | |
| 19 | Marc-Andre ter Stegen | Barcelona | Germany | 23 | |
| 20 | Augusto Batalla | Granada CF | Argentina | 22 |
GC = Goals conceded