| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 11-Sep-2021 | lose |  Athletic Bilbao | 2-0 | away |
| 22-Sep-2021 | lose |  Real Madrid | 6-1 | away |
| 26-Sep-2021 | lose |  Osasuna | 2-3 | home |
| 16-Oct-2021 | lose |  Real Sociedad | 1-0 | away |
| 07-Nov-2021 | draw |  Elche CF | 2-2 | home |
| 22-Nov-2021 | lose |  Rayo Vallecano | 3-1 | away |
| 04-Dec-2021 | win |  Atletico Madrid | 1-2 | away |
| 19-Dec-2021 | lose |  Granada CF | 4-1 | away |
| 02-Jan-2022 | lose |  Barcelona | 0-1 | home |
| 08-Jan-2022 | lose |  Levante | 2-0 | away |
| 22-Jan-2022 | lose |  Villarreal | 3-0 | away |
| 05-Feb-2022 | win |  Cadiz CF | 2-1 | home |
| 20-Feb-2022 | lose |  Real Betis | 2-1 | away |
| 26-Feb-2022 | lose |  Valencia | 0-1 | home |
| 02-Mar-2022 | lose | Real Sociedad | 0-2 | home |
| 06-Mar-2022 | lose |  Celta Vigo | 4-3 | away |
| 14-Mar-2022 | lose | Real Madrid | 0-3 | home |
| 20-Mar-2022 | lose |  Espanyol | 1-0 | away |
| 02-Apr-2022 | lose |  Getafe | 1-0 | away |
| 16-Apr-2022 | lose | Elche CF | 3-0 | away |
| 01-May-2022 | lose | Barcelona | 2-1 | away |
| 07-May-2022 | lose | Granada CF | 2-6 | home |
Overall ( 2 wins,1 draw,19 lost )
Home ( 1 wins,1 draw,6 lost )
Away ( 1 wins,0 draw,13 lost )
OPP = Opposition,
FS = Final score.