| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 13-Sep-2021 | win |  Granada CF | 1-2 | away |
| 23-Sep-2021 | win |  Osasuna | 1-3 | away |
| 26-Sep-2021 | win |  Getafe | 2-0 | home |
| 18-Oct-2021 | win |  CD Alaves | 0-1 | away |
| 24-Oct-2021 | win |  Rayo Vallecano | 3-2 | home |
| 27-Oct-2021 | win |  Valencia | 4-1 | home |
| 21-Nov-2021 | win |  Elche CF | 0-3 | away |
| 04-Dec-2021 | win |  Barcelona | 0-1 | away |
| 12-Dec-2021 | win |  Real Sociedad | 4-0 | home |
| 09-Jan-2022 | draw | Rayo Vallecano | 1-1 | away |
| 18-Jan-2022 | win | CD Alaves | 4-0 | home |
| 13-Feb-2022 | win |  Levante | 2-4 | away |
| 20-Feb-2022 | win |  RCD Mallorca | 2-1 | home |
| 13-Mar-2022 | win |  Athletic Bilbao | 1-0 | home |
| 03-Apr-2022 | win | Osasuna | 4-1 | home |
| 10-May-2022 | win | Valencia | 0-3 | away |
| 15-May-2022 | win | Granada CF | 2-0 | home |
Overall ( 16 wins,1 draw,0 lost )
Home ( 9 wins,0 draw,0 lost )
Away ( 7 wins,1 draw,0 lost )
OPP = Opposition,
FS = Final score.