| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 14-Aug-2021 | win |  CD Alaves | 1-4 | away |
| 22-Aug-2021 | draw |  Levante | 3-3 | away |
| 28-Aug-2021 | win |  Real Betis | 0-1 | away |
| 22-Sep-2021 | win |  RCD Mallorca | 6-1 | home |
| 24-Oct-2021 | win |  Barcelona | 1-2 | away |
| 30-Oct-2021 | win |  Elche CF | 1-2 | away |
| 06-Nov-2021 | win |  Rayo Vallecano | 2-1 | home |
| 21-Nov-2021 | win |  Granada CF | 1-4 | away |
| 01-Dec-2021 | win |  Athletic Bilbao | 1-0 | home |
| 04-Dec-2021 | win |  Real Sociedad | 0-2 | away |
| 12-Dec-2021 | win |  Atletico Madrid | 2-0 | home |
| 22-Dec-2021 | win | Athletic Bilbao | 1-2 | away |
| 08-Jan-2022 | win |  Valencia | 4-1 | home |
| 06-Feb-2022 | win | Granada CF | 1-0 | home |
| 19-Feb-2022 | win | CD Alaves | 3-0 | home |
| 26-Feb-2022 | win | Rayo Vallecano | 0-1 | away |
| 14-Mar-2022 | win | RCD Mallorca | 0-3 | away |
| 02-Apr-2022 | win |  Celta Vigo | 1-2 | away |
| 09-Apr-2022 | win |  Getafe | 2-0 | home |
| 20-Apr-2022 | win |  Osasuna | 1-3 | away |
| 30-Apr-2022 | win |  Espanyol | 4-0 | home |
| 12-May-2022 | win | Levante | 6-0 | home |
| 15-May-2022 | draw |  Cadiz CF | 1-1 | away |
Overall ( 21 wins,2 draw,0 lost )
Home ( 10 wins,0 draw,0 lost )
Away ( 11 wins,2 draw,0 lost )
OPP = Opposition,
FS = Final score.