| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 22-Aug-2021 | lose |  Napoli | 2-0 | away |
| 27-Aug-2021 | lose |  Udinese | 3-0 | away |
| 19-Sep-2021 | lose |  Spezia Calcio | 1-2 | home |
| 22-Sep-2021 | lose |  AC Milan | 2-0 | away |
| 27-Sep-2021 | draw |  Torino | 1-1 | home |
| 01-Oct-2021 | draw |  Cagliari | 1-1 | away |
| 27-Nov-2021 | lose |  Internazionale | 0-2 | home |
| 30-Nov-2021 | lose |  Atalanta | 4-0 | away |
| 11-Dec-2021 | draw |  Juventus | 1-1 | home |
| 19-Dec-2021 | draw |  Sampdoria | 1-1 | away |
| 22-Dec-2021 | lose |  SS Lazio | 1-3 | home |
| 09-Jan-2022 | lose | AC Milan | 0-3 | home |
| 16-Jan-2022 | draw |  Empoli | 1-1 | home |
| 06-Feb-2022 | lose | Napoli | 0-2 | home |
| 12-Feb-2022 | win | Torino | 1-2 | away |
| 27-Feb-2022 | lose | Hellas Verona | 3-1 | away |
| 06-Mar-2022 | lose |  Sassuolo | 1-4 | home |
| 14-Mar-2022 | lose | SS Lazio | 1-0 | away |
| 20-Mar-2022 | lose | Sampdoria | 0-2 | home |
| 02-Apr-2022 | lose | Spezia Calcio | 1-0 | away |
| 10-Apr-2022 | lose | Udinese | 1-2 | home |
| 16-Apr-2022 | lose |  Fiorentina | 1-0 | away |
| 23-Apr-2022 | lose | Atalanta | 1-3 | home |
| 01-May-2022 | lose | Juventus | 2-1 | away |
| 05-May-2022 | lose | Salernitana | 2-1 | away |
Overall ( 1 wins,5 draw,19 lost )
Home ( 0 wins,3 draw,9 lost )
Away ( 1 wins,2 draw,10 lost )
OPP = Opposition,
FS = Final score.