| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 14-Aug-2021 | lose |  VfL Wolfsburg | 1-0 | away |
| 28-Aug-2021 | lose |  1. FC Koln | 2-1 | away |
| 12-Sep-2021 | lose |  Hertha BSC | 1-3 | home |
| 18-Sep-2021 | lose |  Bayern Munich | 7-0 | away |
| 02-Oct-2021 | lose |  RB Leipzig | 3-0 | away |
| 31-Oct-2021 | lose |  Borussia M'gladbach | 2-1 | away |
| 20-Nov-2021 | lose |  Bayer Leverkusen | 1-0 | away |
| 27-Nov-2021 | win |  SC Freiburg | 2-1 | home |
| 14-Dec-2021 | lose |  Arminia Bielefeld | 2-0 | away |
| 18-Dec-2021 | lose | 1. FC Union Berlin | 0-1 | home |
| 15-Jan-2022 | lose |  1. FSV Mainz 05 | 1-0 | away |
| 04-Feb-2022 | draw | Hertha BSC | 1-1 | away |
| 12-Feb-2022 | win | Bayern Munich | 4-2 | home |
| 19-Feb-2022 | draw | VfB Stuttgart | 1-1 | away |
| 27-Feb-2022 | lose | RB Leipzig | 0-1 | home |
| 18-Mar-2022 | lose | Borussia M'gladbach | 0-2 | home |
| 16-Apr-2022 | lose | SC Freiburg | 3-0 | away |
| 24-Apr-2022 | lose |  FC Augsburg | 0-2 | home |
| 14-May-2022 | lose | 1. FC Union Berlin | 3-2 | away |
Overall ( 2 wins,2 draw,15 lost )
Home ( 2 wins,0 draw,5 lost )
Away ( 0 wins,2 draw,10 lost )
OPP = Opposition,
FS = Final score.