| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 15-Aug-2021 | win |  Hertha BSC | 3-1 | home |
| 22-Aug-2021 | lose |  Bayern Munich | 3-2 | away |
| 01-Oct-2021 | win |  SpVgg Greuther Furth | 3-1 | home |
| 15-Oct-2021 | lose |  TSG 1899 Hoffenheim | 5-0 | away |
| 24-Oct-2021 | draw |  Bayer Leverkusen | 2-2 | home |
| 30-Oct-2021 | lose |  Borussia Dortmund | 2-0 | away |
| 21-Nov-2021 | draw |  1. FSV Mainz 05 | 1-1 | away |
| 10-Dec-2021 | lose |  FC Augsburg | 0-2 | home |
| 14-Dec-2021 | win |  VfL Wolfsburg | 2-3 | away |
| 15-Jan-2022 | lose | Bayern Munich | 0-4 | home |
| 22-Jan-2022 | draw | VfL Bochum | 2-2 | away |
| 11-Feb-2022 | lose |  RB Leipzig | 3-1 | away |
| 06-Mar-2022 | lose | TSG 1899 Hoffenheim | 0-1 | home |
| 20-Mar-2022 | draw | Borussia Dortmund | 1-1 | home |
| 01-Apr-2022 | lose | 1. FC Union Berlin | 1-0 | away |
| 09-Apr-2022 | win | 1. FSV Mainz 05 | 3-2 | home |
| 07-May-2022 | lose | VfL Wolfsburg | 0-1 | home |
| 14-May-2022 | lose | VfB Stuttgart | 2-1 | away |
Overall ( 4 wins,4 draw,10 lost )
Home ( 3 wins,2 draw,4 lost )
Away ( 1 wins,2 draw,6 lost )
OPP = Opposition,
FS = Final score.