| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 21-Aug-2021 | win |  Hertha BSC | 1-2 | away |
| 19-Sep-2021 | draw |  Eintracht Frankfurt | 1-1 | home |
| 02-Oct-2021 | lose |  Borussia M'gladbach | 1-3 | home |
| 16-Oct-2021 | lose |  1. FC Union Berlin | 2-0 | away |
| 23-Oct-2021 | lose |  SC Freiburg | 0-2 | home |
| 20-Nov-2021 | draw | Arminia Bielefeld | 2-2 | away |
| 04-Dec-2021 | lose |  1. FSV Mainz 05 | 3-0 | away |
| 11-Dec-2021 | lose | VfB Stuttgart | 0-2 | home |
| 17-Dec-2021 | lose |  Bayern Munich | 4-0 | away |
| 09-Jan-2022 | lose | VfL Bochum | 1-0 | away |
| 23-Jan-2022 | lose |  RB Leipzig | 2-0 | away |
| 12-Mar-2022 | lose | SC Freiburg | 3-2 | away |
| 20-Mar-2022 | lose |  Bayer Leverkusen | 0-2 | home |
| 03-Apr-2022 | lose |  FC Augsburg | 3-0 | away |
| 16-Apr-2022 | lose |  Borussia Dortmund | 6-1 | away |
| 14-May-2022 | draw | Bayern Munich | 2-2 | home |
Overall ( 1 wins,3 draw,12 lost )
Home ( 0 wins,2 draw,4 lost )
Away ( 1 wins,1 draw,8 lost )
OPP = Opposition,
FS = Final score.