| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 21-Aug-2021 | lose |  VfL Bochum | 2-0 | away |
| 25-Sep-2021 | lose |  Bayer Leverkusen | 1-0 | away |
| 16-Oct-2021 | lose |  Borussia Dortmund | 3-1 | away |
| 05-Nov-2021 | draw |  Borussia M'gladbach | 1-1 | home |
| 26-Nov-2021 | lose | VfB Stuttgart | 2-1 | away |
| 18-Dec-2021 | lose |  Eintracht Frankfurt | 1-0 | away |
| 08-Jan-2022 | lose |  RB Leipzig | 4-1 | away |
| 22-Jan-2022 | lose | SpVgg Greuther Furth | 2-1 | away |
| 18-Feb-2022 | win | Bayer Leverkusen | 3-2 | home |
| 26-Feb-2022 | lose | 1. FC Union Berlin | 3-1 | away |
| 16-Mar-2022 | lose | Borussia Dortmund | 0-1 | home |
| 03-Apr-2022 | draw | Borussia M'gladbach | 1-1 | away |
| 06-Apr-2022 | lose |  FC Augsburg | 2-1 | away |
| 22-Apr-2022 | lose |  VfL Wolfsburg | 5-0 | away |
Overall ( 1 wins,2 draw,11 lost )
Home ( 1 wins,1 draw,1 lost )
Away ( 0 wins,1 draw,10 lost )
OPP = Opposition,
FS = Final score.