| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 14-Aug-2021 | lose |  Borussia Dortmund | 5-2 | away |
| 25-Sep-2021 | draw |  1. FC Koln | 1-1 | home |
| 03-Oct-2021 | win |  Bayern Munich | 1-2 | away |
| 16-Oct-2021 | lose |  Hertha BSC | 1-2 | home |
| 24-Oct-2021 | lose |  VfL Bochum | 2-0 | away |
| 30-Oct-2021 | draw |  RB Leipzig | 1-1 | home |
| 12-Dec-2021 | win |  Bayer Leverkusen | 5-2 | home |
| 15-Dec-2021 | win |  Borussia M'gladbach | 2-3 | away |
| 21-Jan-2022 | lose | Arminia Bielefeld | 0-2 | home |
| 12-Feb-2022 | lose |  VfL Wolfsburg | 0-2 | home |
| 19-Feb-2022 | lose | 1. FC Koln | 1-0 | away |
| 26-Feb-2022 | lose | Bayern Munich | 0-1 | home |
| 13-Mar-2022 | win | VfL Bochum | 2-1 | home |
| 10-Apr-2022 | lose |  SC Freiburg | 1-2 | home |
| 17-Apr-2022 | lose | 1. FC Union Berlin | 2-0 | away |
| 23-Apr-2022 | draw |  TSG 1899 Hoffenheim | 2-2 | home |
| 02-May-2022 | lose | Bayer Leverkusen | 2-0 | away |
| 08-May-2022 | draw | Borussia M'gladbach | 1-1 | home |
| 14-May-2022 | draw |  1. FSV Mainz 05 | 2-2 | away |
Overall ( 4 wins,5 draw,10 lost )
Home ( 2 wins,4 draw,5 lost )
Away ( 2 wins,1 draw,5 lost )
OPP = Opposition,
FS = Final score.