| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 14-Aug-2021 | lose |  VfB Stuttgart | 5-1 | away |
| 21-Aug-2021 | draw | Arminia Bielefeld | 1-1 | home |
| 28-Aug-2021 | lose |  1. FSV Mainz 05 | 3-0 | away |
| 11-Sep-2021 | lose |  VfL Wolfsburg | 0-2 | home |
| 24-Sep-2021 | lose |  Bayern Munich | 1-3 | home |
| 16-Oct-2021 | lose | VfL Bochum | 0-1 | home |
| 30-Oct-2021 | lose |  SC Freiburg | 3-1 | away |
| 07-Nov-2021 | lose |  Eintracht Frankfurt | 1-2 | home |
| 20-Nov-2021 | lose |  Borussia M'gladbach | 4-0 | away |
| 04-Dec-2021 | lose |  Bayer Leverkusen | 7-1 | away |
| 15-Dec-2021 | lose |  Borussia Dortmund | 3-0 | away |
| 16-Jan-2022 | draw | Arminia Bielefeld | 2-2 | away |
| 06-Feb-2022 | lose | VfL Wolfsburg | 4-1 | away |
| 26-Feb-2022 | draw |  1. FC Koln | 1-1 | home |
| 05-Mar-2022 | lose | VfL Bochum | 2-1 | away |
| 09-Apr-2022 | lose | Borussia M'gladbach | 0-2 | home |
| 07-May-2022 | lose | Borussia Dortmund | 1-3 | home |
| 14-May-2022 | lose |  FC Augsburg | 2-1 | away |
Overall ( 0 wins,3 draw,15 lost )
Home ( 0 wins,2 draw,6 lost )
Away ( 0 wins,1 draw,9 lost )
OPP = Opposition,
FS = Final score.