| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 15-Aug-2021 | win |  Rayo Vallecano | 3-0 | home |
| 23-Aug-2021 | win |  Getafe | 0-1 | away |
| 22-Sep-2021 | win |  Valencia | 3-1 | home |
| 25-Sep-2021 | win |  Espanyol | 2-0 | home |
| 17-Oct-2021 | win |  Celta Vigo | 0-1 | away |
| 24-Oct-2021 | win |  Levante | 5-3 | home |
| 30-Oct-2021 | win |  Osasuna | 2-0 | home |
| 07-Nov-2021 | win |  Real Betis | 0-2 | away |
| 28-Nov-2021 | lose |  Real Madrid | 2-1 | away |
| 04-Dec-2021 | win |  Villarreal | 1-0 | home |
| 11-Dec-2021 | win |  Athletic Bilbao | 0-1 | away |
| 18-Dec-2021 | win |  Atletico Madrid | 2-1 | home |
| 21-Dec-2021 | draw |  Barcelona | 1-1 | home |
| 03-Jan-2022 | win |  Cadiz CF | 0-1 | away |
| 09-Jan-2022 | win | Getafe | 1-0 | home |
| 19-Jan-2022 | draw | Valencia | 1-1 | away |
| 11-Feb-2022 | win |  Elche CF | 2-0 | home |
| 20-Feb-2022 | draw | Espanyol | 1-1 | away |
| 27-Feb-2022 | win | Real Betis | 2-1 | home |
| 17-Apr-2022 | lose | Real Madrid | 2-3 | home |
| 21-Apr-2022 | win | Levante | 2-3 | away |
| 29-Apr-2022 | draw | Cadiz CF | 1-1 | home |
| 22-May-2022 | win | Athletic Bilbao | 1-0 | home |
Overall ( 17 wins,4 draw,2 lost )
Home ( 11 wins,2 draw,1 lost )
Away ( 6 wins,2 draw,1 lost )
OPP = Opposition,
FS = Final score.