| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 22-Aug-2021 | draw |  1. FC Union Berlin | 2-2 | home |
| 27-Aug-2021 | lose |  Borussia Dortmund | 3-2 | away |
| 11-Sep-2021 | lose |  1. FSV Mainz 05 | 0-2 | home |
| 25-Sep-2021 | win |  VfL Wolfsburg | 3-1 | home |
| 02-Oct-2021 | lose | VfB Stuttgart | 3-1 | away |
| 23-Oct-2021 | lose |  Bayern Munich | 4-0 | away |
| 06-Nov-2021 | lose | VfL Bochum | 2-0 | away |
| 27-Nov-2021 | win | SpVgg Greuther Furth | 3-6 | away |
| 04-Dec-2021 | win |  Eintracht Frankfurt | 3-2 | home |
| 15-Dec-2021 | draw |  Bayer Leverkusen | 2-2 | away |
| 18-Dec-2021 | draw |  Borussia M'gladbach | 1-1 | home |
| 08-Jan-2022 | win |  FC Augsburg | 3-1 | home |
| 22-Jan-2022 | lose | Borussia Dortmund | 2-3 | home |
| 05-Feb-2022 | lose | 1. FSV Mainz 05 | 2-0 | away |
| 19-Feb-2022 | win | VfL Wolfsburg | 1-2 | away |
| 25-Feb-2022 | win | VfB Stuttgart | 2-1 | home |
| 19-Mar-2022 | lose |  Hertha BSC | 3-0 | away |
| 02-Apr-2022 | lose | VfL Bochum | 1-2 | home |
| 10-Apr-2022 | lose |  RB Leipzig | 3-0 | away |
| 30-Apr-2022 | lose |  SC Freiburg | 3-4 | home |
Overall ( 6 wins,3 draw,11 lost )
Home ( 4 wins,2 draw,4 lost )
Away ( 2 wins,1 draw,7 lost )
OPP = Opposition,
FS = Final score.